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[総説]寄生虫感染による宿主免疫応答の失調について
http://hdl.handle.net/20.500.12000/0002016353
http://hdl.handle.net/20.500.12000/0002016353843b8c8b-9665-4efb-a314-2b08f20c8a4b
名前 / ファイル | ライセンス | アクション |
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Item type | デフォルトアイテムタイプ(フル)(1) | |||||||||
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公開日 | 2014-07-18 | |||||||||
タイトル | ||||||||||
タイトル | [総説]寄生虫感染による宿主免疫応答の失調について | |||||||||
言語 | ja | |||||||||
タイトル | ||||||||||
タイトル | Altered immunological responsiveness during the parasitic infections | |||||||||
言語 | en | |||||||||
作成者 |
佐藤, 良也
× 佐藤, 良也
× Sato, Yoshiya
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アクセス権 | ||||||||||
アクセス権 | open access | |||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
権利情報 | ||||||||||
言語 | ja | |||||||||
権利情報 | 琉球医学会 | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | Parasite infections have been shown to induce alteration in the immune responsiveness of host, including the immunosuppression. Such alterations are of obvious potential importance in the pathogenesis of parasitic infections, development of the acquired resistance and a long term survival of parasite in the host. The mechanisms involved have been studied well in some parasitic infections such as malaria, trypanosomiasis, toxoplasmosis, schistosomiasis and trichinosis, but the subject remains still unclear. The speculations have centered on the activation of suppressor cells (T- tymphocytes and macrophages), exhaustion of lymphocyte responsiveness following the polyclonal lymphocyte activation and alteration of macrophage function in the presentation of antigen. Besides these speculations, several findings have been interpreted variously as the manifestations of suppressor products released by parasites, and the induction of anti-thymocyte autoantiboies by polyclonal B lymphocyte activation has also been suggested to play a role in the development of generalized immunosuppression. It can be clearly pointed out, however, that the complex fectors originated in parasite itself and unique immunostimulatory forms of parasitic infections take part as a very significant factor in the occurrence of the immune alterations. It is surmised that the altered immune responsiveness plays an important role in the completion of host-parasite relationships, and further analytical studies must be continued in relation with the basic immunoregulatory mechanisms. | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 論文 | |||||||||
出版者 | ||||||||||
言語 | ja | |||||||||
出版者 | 琉球大学医学部 | |||||||||
出版者 | ||||||||||
言語 | en | |||||||||
出版者 | Faculty of Medicine, University of the Ryukyus | |||||||||
言語 | ||||||||||
言語 | jpn | |||||||||
資源タイプ | ||||||||||
資源タイプ | journal article | |||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
出版タイプ | ||||||||||
出版タイプ | VoR | |||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 0285-9270 | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AN00250763 | |||||||||
収録物名 | ||||||||||
言語 | ja | |||||||||
収録物名 | 琉球大学保健学医学雑誌=Ryukyu University Journal of Health Sciences and Medicine | |||||||||
書誌情報 |
巻 4, 号 3, p. 198-213 |