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[原著]Study on the Estimate of the Number of Genetic Factors Responsible for Blood Sugar
http://hdl.handle.net/20.500.12000/0002016425
http://hdl.handle.net/20.500.12000/0002016425359da2f9-7dc9-4acc-a343-d96b0cde1d9a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
v1p310.pdf
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| Item type | デフォルトアイテムタイプ（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2014-07-18 | |||||||||
| タイトル | ||||||||||
| タイトル | [原著]Study on the Estimate of the Number of Genetic Factors Responsible for Blood Sugar | |||||||||
| 言語 | ja | |||||||||
| 作成者 |
Mimura, Goro
× Mimura, Goro
× Fujioka, Setuyo
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 権利情報 | ||||||||||
| 言語 | ja | |||||||||
| 権利情報 | 琉球医学会 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Heredity has been presumed as a major factor in the development of diabetes mellitus. The heredity of diabetes mellitus was certified by studies on familial incidence, and by the study of diabetes mellitus in twins. Refering to the above mentioned studies, one of the authors, Mimura has already reported in detail (Mimura et al 1970). If diabetes mellitus is heritable, it is necessary to determine the mode of inheritance, i.e., whether it has a monogenetic or polygenetic control mechanism. In 1962, Mimura concluded that it was difficult to explain the mode of inheritance of diabetes mellitus by a simple recessive gene or by a dominant gene, from the results of analyzing family data of diabetes mellitus. Since then, Mimura has advocated that polygenetic inheritance was the most suitable explanation for the development of the disease (Mimura et al 1964 a. , b. , 1970). Namely, Mimura pointed out that the genetic analysis of blood sugar which has been regarded and used as one of the most important and indispensable factors in the diagnosis of diabetes mellitus was one of the means to make clear the hereditary mechanism of diabetes mellitus. And Mimura presumed that diabetes mellitus develops due to an abnormality in the blood sugar control mechanism. If this is true, there is no theoretical contradiction, in the cases where application of the mode of blood sugar inheritance to the hereditary mechanism of diabetes mellitus is concerned. Mimura has made clear that blood sugar is a continuous character and is controlled polygenetically because of the frequency distribution of blood sugar. If the blood sugar is controlled by a polygene, it is necessary to calculate the number of gene loci. Mimura and Kodera (1973) already calculated the number of gene loci in essential hypertension by using the methods of Davenport (1910,1913) , Castle (1921) and Wright (1934). In this paper the number of gene loci in diabetes mellitus was calculated by using the methods of Castle, Wright and Furusho (1973). | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 論文 | |||||||||
| 出版者 | ||||||||||
| 出版者 | 琉球大学保健学部 | |||||||||
| 言語 | ja | |||||||||
| 出版者 | ||||||||||
| 出版者 | College of Health Sciences, University of the Ryukyus | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0285-9270 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AN00250763 | |||||||||
| 収録物名 | ||||||||||
| 収録物名 | 琉球大学保健学医学雑誌＝Ryukyu University Journal of Health Sciences and Medicine | |||||||||
| 言語 | ja | |||||||||
| 書誌情報 |
巻 1, 号 4, p. 310-314 |
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