| Item type |
デフォルトアイテムタイプ（フル）(1) |
| 公開日 |
2015-12-28 |
| タイトル |
|
|
タイトル |
[原著]Increased plasma tacrolimus concentration after single intravenous administration of voriconazole : a case of drug–drug interaction |
|
言語 |
ja |
| 作成者 |
Shiohira, Hideo
Yamada, Satoshi
Uehara, Hitoshi
Hokama, Nobuo
Ueda, Shinichiro
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
tacrolimus |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
voriconazole |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
CYP3A4/5 |
| 主題 |
|
|
言語 |
ja |
|
主題Scheme |
Other |
|
主題 |
drug–drug interaction |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
therapeutic drug monitoring |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Tacrolimus, as one of cytochrome P450 (CYP) 4/5 substrates is known to have many drug–drug interactions. Metabolism of tacrolimus is inhibited by many drugs, such as the azole antifungal agents due to their effects on CYP 3A4/5. Implementation of therapeutic drug monitoring is commended during tacrolimus treatment for maintaining optimal plasma concentration levels, and to avoid its toxicity. We herein report a case of a 58-year-old female patient with lupus nephritis whose plasma concentration of orally ministered tacrolimus increased after a single administration of 300 mg voriconazole for suspected Aspergillus infection. Our observations were the result of therapeutic drug monitoring before the second administration of voriconazole. Although tacrolimus dose did not vary, the plasma tacrolimus concentration was markedly increased and concentration dose ratio was 2.1 fold more than prior to voriconazole treatment. This case suggests that even after a single intravenous administration of voriconazole, the plasma concentration of tacrolimus may increase. Dose optimization of tacrolimus by therapeutic drug monitoring soon after the first dose of voriconazole is therefore warranted to minimize the risk of tacrolimus toxicity. |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
論文 |
| 出版者 |
|
|
出版者 |
琉球医学会 |
|
言語 |
ja |
| 出版者 |
|
|
出版者 |
Ryukyu Medical Association |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1346-888X |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN10369445 |
| 収録物名 |
|
|
収録物名 |
琉球医学会誌 = Ryukyu Medical Journal |
|
言語 |
ja |
| 書誌情報 |
巻 33,
号 1-3,
p. 41-44
|
v33(1-3)p41.pdf
