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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 33巻1-3号
  1. 部局別インデックス
  2. その他

[原著]Increased plasma tacrolimus concentration after single intravenous administration of voriconazole : a case of drug–drug interaction

http://hdl.handle.net/20.500.12000/0002016871
http://hdl.handle.net/20.500.12000/0002016871
f6e8c61b-295c-4b73-a5ba-e97e54eda6a5
名前 / ファイル ライセンス アクション
v33(1-3)p41.pdf v33(1-3)p41.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2015-12-28
タイトル
タイトル [原著]Increased plasma tacrolimus concentration after single intravenous administration of voriconazole : a case of drug–drug interaction
言語 ja
作成者 Shiohira, Hideo

× Shiohira, Hideo

en Shiohira, Hideo

Yamada, Satoshi

× Yamada, Satoshi

en Yamada, Satoshi

Uehara, Hitoshi

× Uehara, Hitoshi

en Uehara, Hitoshi

Hokama, Nobuo

× Hokama, Nobuo

en Hokama, Nobuo

Ueda, Shinichiro

× Ueda, Shinichiro

en Ueda, Shinichiro

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
主題
言語 ja
主題Scheme Other
主題 drug–drug interaction
内容記述
内容記述タイプ Other
内容記述 Tacrolimus, as one of cytochrome P450 (CYP) 4/5 substrates is known to have many drug–drug interactions. Metabolism of tacrolimus is inhibited by many drugs, such as the azole antifungal agents due to their effects on CYP 3A4/5. Implementation of therapeutic drug monitoring is commended during tacrolimus treatment for maintaining optimal plasma concentration levels, and to avoid its toxicity. We herein report a case of a 58-year-old female patient with lupus nephritis whose plasma concentration of orally ministered tacrolimus increased after a single administration of 300 mg voriconazole for suspected Aspergillus infection. Our observations were the result of therapeutic drug monitoring before the second administration of voriconazole. Although tacrolimus dose did not vary, the plasma tacrolimus concentration was markedly increased and concentration dose ratio was 2.1 fold more than prior to voriconazole treatment. This case suggests that even after a single intravenous administration of voriconazole, the plasma concentration of tacrolimus may increase. Dose optimization of tacrolimus by therapeutic drug monitoring soon after the first dose of voriconazole is therefore warranted to minimize the risk of tacrolimus toxicity.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 jpn
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346-888X
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 33, 号 1-3, p. 41-44
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