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麻疹の動物モデルの作成
http://hdl.handle.net/20.500.12000/0002016894
http://hdl.handle.net/20.500.12000/00020168947f23a868-4ecf-45b4-a88e-cbe662454384
名前 / ファイル | ライセンス | アクション |
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Vol37(1-4)p1.pdf
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Item type | デフォルトアイテムタイプ(フル)(1) | |||||||||
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公開日 | 2019-12-02 | |||||||||
タイトル | ||||||||||
タイトル | 麻疹の動物モデルの作成 | |||||||||
言語 | ja | |||||||||
タイトル | ||||||||||
タイトル | Development of mouse model for measles | |||||||||
言語 | en | |||||||||
作成者 |
大野, 真治
× 大野, 真治
× Ohno, Shinji
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アクセス権 | ||||||||||
アクセス権 | open access | |||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
権利情報 | ||||||||||
言語 | ja | |||||||||
権利情報 | 琉球医学会 | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Measles | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | CD150 | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | mouse model | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | Measles virus (MV) causes feverous disease exclusively in human. Despite the availability of effective vaccine, measles is still a leading cause of mortality and morbidity among children mainly in developing countries. The virus does not infect laboratory mouse, because MV do not use mouse CD150 as a cellular receptor. In our previous data, the V domain of human CD150 is necessary and sufficient for MV infection. We developed a recombinant mouse expressing chimeric CD150 in which the V domain was replaced with that of human. MV infects the mouse on the condition that type I interferon system was abolished. In the MV-infected mouse, MV was detected in lymphoid organ and the number of the T cell in spleen was reduced. Furthermore, MV causes immune suppression in the model mouse, as observed in measles patients. We believe that our measles model is useful to analyze the pathogenicity of MV in vivo. | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 論文 | |||||||||
出版者 | ||||||||||
言語 | ja | |||||||||
出版者 | 琉球医学会 | |||||||||
出版者 | ||||||||||
言語 | en | |||||||||
出版者 | Ryukyu Medical Association | |||||||||
言語 | ||||||||||
言語 | jpn | |||||||||
資源タイプ | ||||||||||
資源タイプ | journal article | |||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
出版タイプ | ||||||||||
出版タイプ | VoR | |||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 1346-888X | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AN10369445 | |||||||||
収録物名 | ||||||||||
言語 | ja | |||||||||
収録物名 | 琉球医学会誌 = Ryukyu Medical Journal | |||||||||
書誌情報 |
巻 37, 号 1-4, p. 1-3 |