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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 37巻1-4号
  1. 部局別インデックス
  2. その他

麻疹の動物モデルの作成

http://hdl.handle.net/20.500.12000/0002016894
http://hdl.handle.net/20.500.12000/0002016894
7f23a868-4ecf-45b4-a88e-cbe662454384
名前 / ファイル ライセンス アクション
Vol37(1-4)p1.pdf Vol37(1-4)p1.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2019-12-02
タイトル
タイトル 麻疹の動物モデルの作成
言語 ja
作成者 大野, 真治

× 大野, 真治

ja 大野, 真治

Ohno, Shinji

× Ohno, Shinji

en Ohno, Shinji

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 Measles
言語 en
主題Scheme Other
主題 CD150
言語 en
主題Scheme Other
主題 mouse model
内容記述
内容記述タイプ Other
内容記述 Measles virus (MV) causes feverous disease exclusively in human. Despite the availability of effective vaccine, measles is still a leading cause of mortality and morbidity among children mainly in developing countries. The virus does not infect laboratory mouse, because MV do not use mouse CD150 as a cellular receptor. In our previous data, the V domain of human CD150 is necessary and sufficient for MV infection. We developed a recombinant mouse expressing chimeric CD150 in which the V domain was replaced with that of human. MV infects the mouse on the condition that type I interferon system was abolished. In the MV-infected mouse, MV was detected in lymphoid organ and the number of the T cell in spleen was reduced. Furthermore, MV causes immune suppression in the model mouse, as observed in measles patients. We believe that our measles model is useful to analyze the pathogenicity of MV in vivo.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 jpn
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346-888X
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 37, 号 1-4, p. 1-3
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