{"_buckets": {"deposit": "6a7f4011-6667-488a-9cf4-e8cbfc3493fe"}, "_deposit": {"id": "2016899", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2016899"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02016899", "sets": ["1642838231558", "1642838412624"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "Telmisartan inhibits PAI-1 mRNA expression independently of peroxisome proliferator-activated receptor \u03b3 in vascular endothelial cells", "subitem_1551255648112": "ja"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Uehara, Ken", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Sunagawa, Masanori", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Nakamura-Higa, Mariko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Suzuki, Mikio", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kosugi, Tadayoshi", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "ja", "subitem_1522651041219": "\u7409\u7403\u533b\u5b66\u4f1a"}]}, "item_1617186609386": {"attribute_name": "Subject", "attribute_value_mlt": [{"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "telmisartan"}, {"subitem_1522299896455": "ja", "subitem_1522300014469": "Other", "subitem_1523261968819": "peroxisome proliferator-activated receptor \u03b3"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "angiotensin II type 1 receptor antagonist"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "vascular endothelial cells"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "plasminogen activator inhibitor 1"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "To investigate whether telmisartan (TMS), a unique angiotensin II type 1 receptor(AT1R) antagonist with selective peroxisome proliferator-activated receptor (PPAR) \u03b3- modulating activity, inhibits plasminogen activator inhibitor 1 (PAI-1) and/or stimulates issue-type plasminogen activator (t-PA) mRNA expression in vascular endothelial cells(VECs), we cultured VECs obtained from the thoracic aorta of Long Evans Tokushima Otsuka rats by the explant method. mRNA expression was measured using comparative reverse transcription polymerase chain reaction. The binding activity of PPAR\u03b3 to its coactivator (CREB-binding protein) was determined by enzyme-linked immunosorbent assay. The synthetic PPAR\u03b3 agonists troglitazone (TRO) and TMS activated PPAR\u03b3 with EC_50 values of 0.95 and 161\u03bcM, respectively, under cell-free conditions. PPAR\u03b3 mRNA was constitutively expressed in cultured VECs, unlike PPAR\u03b1 and PPAR\u03b2. PAI-1 mRNA expression was significantly downregulated by TMS, and this downregulation was not abolished by the presence of the PPAR\u03b3 antagonist GW9662. The expression of t-PA mRNA was not altered by TMS treatment. TRO had no effect on PAI-1 and t-PA mRNA expressions.PAI-1 mRNA expression was significantly decreased by GW9662. In conclusion, TMS inhibited PAI-1 mRNA expression independently of PPAR\u03b3 activation. Intrinsic PPAR\u03b3 agonists, but not extrinsic PPAR\u03b3 agonists, may be involved in basal mRNA expression of PAI-1 in VECs", "subitem_description_type": "Other"}, {"subitem_description": "\u8ad6\u6587", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "ja", "subitem_1522300316516": "\u7409\u7403\u533b\u5b66\u4f1a"}, {"subitem_1522300295150": "en", "subitem_1522300316516": "Ryukyu Medical Association"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "eng"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "1346-888X"}, {"subitem_1522646500366": "NCID", "subitem_1522646572813": "AN10369445"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "ja", "subitem_1522650091861": "\u7409\u7403\u533b\u5b66\u4f1a\u8a8c = Ryukyu Medical Journal"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueNumber": "1-4", "bibliographicPageEnd": "50", "bibliographicPageStart": "41", "bibliographicVolumeNumber": "37"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "Vol37(1-4)p41.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2016899/files/Vol37(1-4)p41.pdf"}, "version_id": "aee34319-02a4-4045-af51-6207d4c6fa0c"}]}, "item_title": "Telmisartan inhibits PAI-1 mRNA expression independently of peroxisome proliferator-activated receptor \u03b3 in vascular endothelial cells", "item_type_id": "15", "owner": "1", "path": ["1642838231558", "1642838412624"], "permalink_uri": "http://hdl.handle.net/20.500.12000/0002016899", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2019-11-29"}, "publish_date": "2019-11-29", "publish_status": "0", "recid": "2016899", "relation": {}, "relation_version_is_last": true, "title": ["Telmisartan inhibits PAI-1 mRNA expression independently of peroxisome proliferator-activated receptor \u03b3 in vascular endothelial cells"], "weko_shared_id": -1}