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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 37巻1-4号
  1. 部局別インデックス
  2. その他

Telmisartan inhibits PAI-1 mRNA expression independently of peroxisome proliferator-activated receptor γ in vascular endothelial cells

http://hdl.handle.net/20.500.12000/0002016899
http://hdl.handle.net/20.500.12000/0002016899
c0847e0b-e434-4cfd-97ab-a8477c70de8c
名前 / ファイル ライセンス アクション
Vol37(1-4)p41.pdf Vol37(1-4)p41.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2019-11-29
タイトル
タイトル Telmisartan inhibits PAI-1 mRNA expression independently of peroxisome proliferator-activated receptor γ in vascular endothelial cells
言語 ja
作成者 Uehara, Ken

× Uehara, Ken

en Uehara, Ken

Sunagawa, Masanori

× Sunagawa, Masanori

en Sunagawa, Masanori

Nakamura-Higa, Mariko

× Nakamura-Higa, Mariko

en Nakamura-Higa, Mariko

Suzuki, Mikio

× Suzuki, Mikio

en Suzuki, Mikio

Kosugi, Tadayoshi

× Kosugi, Tadayoshi

en Kosugi, Tadayoshi

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 ja
主題Scheme Other
主題 peroxisome proliferator-activated receptor γ
内容記述
内容記述タイプ Other
内容記述 To investigate whether telmisartan (TMS), a unique angiotensin II type 1 receptor(AT1R) antagonist with selective peroxisome proliferator-activated receptor (PPAR) γ- modulating activity, inhibits plasminogen activator inhibitor 1 (PAI-1) and/or stimulates issue-type plasminogen activator (t-PA) mRNA expression in vascular endothelial cells(VECs), we cultured VECs obtained from the thoracic aorta of Long Evans Tokushima Otsuka rats by the explant method. mRNA expression was measured using comparative reverse transcription polymerase chain reaction. The binding activity of PPARγ to its coactivator (CREB-binding protein) was determined by enzyme-linked immunosorbent assay. The synthetic PPARγ agonists troglitazone (TRO) and TMS activated PPARγ with EC_50 values of 0.95 and 161μM, respectively, under cell-free conditions. PPARγ mRNA was constitutively expressed in cultured VECs, unlike PPARα and PPARβ. PAI-1 mRNA expression was significantly downregulated by TMS, and this downregulation was not abolished by the presence of the PPARγ antagonist GW9662. The expression of t-PA mRNA was not altered by TMS treatment. TRO had no effect on PAI-1 and t-PA mRNA expressions.PAI-1 mRNA expression was significantly decreased by GW9662. In conclusion, TMS inhibited PAI-1 mRNA expression independently of PPARγ activation. Intrinsic PPARγ agonists, but not extrinsic PPARγ agonists, may be involved in basal mRNA expression of PAI-1 in VECs
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346-888X
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 37, 号 1-4, p. 41-50
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