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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学研究科

Spontaneous pulmonary emphysema in mice lacking all three nitric oxide synthase isoforms

http://hdl.handle.net/20.500.12000/0002017923
http://hdl.handle.net/20.500.12000/0002017923
468fbeb2-d346-4a68-ab53-50e6171ba9f1
名前 / ファイル ライセンス アクション
s41598-021-01453-6.pdf s41598-021-01453-6.pdf (2.4 MB)
Item type 琉球大学リポジトリ登録用アイテムタイプ(1)
公開日 2022-05-12
タイトル
タイトル Spontaneous pulmonary emphysema in mice lacking all three nitric oxide synthase isoforms
言語 en
作成者 Kato, Kaori

× Kato, Kaori

en Kato, Kaori

Tsutsui, Masato

× Tsutsui, Masato

en Tsutsui, Masato

Noguchi, Shingo

× Noguchi, Shingo

en Noguchi, Shingo

Iha, Yukitoshi

× Iha, Yukitoshi

en Iha, Yukitoshi

Naito, Keisuke

× Naito, Keisuke

en Naito, Keisuke

Ogoshi, Takaaki

× Ogoshi, Takaaki

en Ogoshi, Takaaki

Nishida, Chinatsu

× Nishida, Chinatsu

en Nishida, Chinatsu

Tahara, Masahiro

× Tahara, Masahiro

en Tahara, Masahiro

Yamashita, Hirotaka

× Yamashita, Hirotaka

en Yamashita, Hirotaka

Wang, Ke‑Yong

× Wang, Ke‑Yong

en Wang, Ke‑Yong

Toyohira, Yumiko

× Toyohira, Yumiko

en Toyohira, Yumiko

Yanagihara, Nobuyuki

× Yanagihara, Nobuyuki

en Yanagihara, Nobuyuki

Masuzaki, Hiroaki

× Masuzaki, Hiroaki

en Masuzaki, Hiroaki

Shimokawa, Hiroaki

× Shimokawa, Hiroaki

en Shimokawa, Hiroaki

Akihide, Tanimoto

× Akihide, Tanimoto

en Akihide, Tanimoto

Yatera, Kazuhiro

× Yatera, Kazuhiro

en Yatera, Kazuhiro

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報Resource https://creativecommons.org/licenses/by/4.0/
権利情報 Creative Commons Attribution 4.0 International License
言語 en
権利情報 © The Author(s) 2021
内容記述
内容記述タイプ Abstract
内容記述 The roles of endogenous nitric oxide (NO) derived from the entire NO synthases (NOSs) system have yet to be fully elucidated. We addressed this issue in mice in which all three NOS isoforms were deleted. Under basal conditions, the triple n/i/eNOSs−/− mice displayed significantly longer mean alveolar linear intercept length, increased alveolar destructive index, reduced lung elastic fiber content, lower lung field computed tomographic value, and greater end-expiratory lung volume as compared with wild-type (WT) mice. None of single NOS−/− or double NOSs−/− genotypes showed such features. These findings were observed in the triple n/i/eNOSs−/− mice as early as 4 weeks after birth. Cyclopaedic and quantitative comparisons of mRNA expression levels between the lungs of WT and triple n/i/eNOSs−/− mice by cap analysis of gene expression (CAGE) revealed that mRNA expression levels of three Wnt ligands and ten Wnt/β-catenin signaling components were signifcantly reduced in the lungs of triple n/i/eNOSs−/− mice. These results provide the first direct evidence that complete disruption of all three NOS genes results in spontaneous pulmonary emphysema in juvenile mice in vivo possibly through down-regulation of the Wnt/β-catenin signaling pathway, demonstrating a novel preventive role of the endogenous NO/NOS system in the occurrence of pulmonary emphysema.
言語 en
出版者
言語 en
出版者 Springer Nature
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/s41598-021-01453-6
収録物識別子
収録物識別子タイプ EISSN
収録物識別子 2045-2322
収録物名
言語 en
収録物名 Scientific Reports
書誌情報
巻 11, p. 22088, 発行日 2021-11-11
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