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  1. 学位論文
  2. 博士論文
  3. 医学研究科
  1. 部局別インデックス
  2. 医学研究科

日本人2型糖尿病患者における糖尿病性網膜症の発症あるいは増悪に関連する因子の性差に関する後方視的探索研究

http://hdl.handle.net/20.500.12000/0002018008
http://hdl.handle.net/20.500.12000/0002018008
bb6f7fb7-3c21-439f-873d-d4007c27fe7f
名前 / ファイル ライセンス アクション
iken519abstract.pdf iken519abstract.pdf (862 KB)
iken519review.pdf iken519review.pdf (993 KB)
iken519text.pdf iken519text.pdf (5.7 MB)
Item type 琉球大学リポジトリ登録用アイテムタイプ(1)
公開日 2022-06-07
タイトル
タイトル Retrospective exploratory analyses on gender differences in determinants for incidence and progression of diabetic retinopathy in Japanese patients with type 2 diabetes mellitus
言語 en
タイトル
タイトル 日本人2型糖尿病患者における糖尿病性網膜症の発症あるいは増悪に関連する因子の性差に関する後方視的探索研究
言語 ja
作成者 中山, 良研

× 中山, 良研

en Nakayama, Yoshiro

ja 中山, 良研

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 © The Japan Endocrine Society
主題
言語 en
主題Scheme Other
主題 Diabetic retinopathy
主題
言語 en
主題Scheme Other
主題 Gender difference
主題
言語 en
主題Scheme Other
主題 Gender-specific determinant
主題
言語 en
主題Scheme Other
主題 Retrospective study
内容記述
内容記述タイプ Abstract
内容記述 Gender differences in risks for macrovascular complications in type 2 diabetes mellitus (T2DM) have been well established. However, the impact of gender differences on diabetic retinopathy (DR) has not been fully elucidated. We therefore retrospectively explored gender-specific determinants for DR in patients with T2DM in a small sized Japanese cohort in Okinawa. There were 214 patients who were diagnosed as no DR (n = 142) and non-proliferative DR (n = 72) in 2009. During the follow-up of median 7 years, 41/142 of incidence, 26/72 of progression, and 67/214 of incidence and progression were observed, respectively. DR was assessed using the modified international clinical DR severity scales. The risks for incidence, progression as well as incidence and progression of DR were comparable between men and women, respectively. Cox proportional hazard models in multivariate analyses demonstrated that the only common determinant in both men and women for DR was the duration of T2DM. Regarding gender-specific determinants, lower level of serum albumin in men as well as higher HbA1c, lower level of estimated glomerular filtration rate, and lower level of serum uric acid in women were extracted, respectively. Although precise mechanisms for such gender-specific determinants of DR still remain unsolved, the present study would highlight a couple of factors associated with gender-specific determinants for DR in a limited numbers of Japanese cohort. Prospective observational studies on gender-specific determinants of DR in a large scale cohort are warranted to further clarify underlying mechanisms.
言語 en
出版者
言語 ja
出版者 琉球大学
出版者
言語 en
出版者 University of the Ryukyus
言語
言語 eng
資源タイプ
資源タイプ doctoral thesis
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1507/endocrj.EJ20-0630
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0918-8959
収録物名
言語 en
収録物名 Endocrine Journal
書誌情報
巻 68, 号 6, p. 655-669, 発行日 2021
学位授与番号
学位授与番号 甲第519号
学位名
学位名 博士(医学)
言語 ja
学位授与年月日
学位授与年月日 2021-03-23
学位授与機関
学位授与機関識別子 18001
学位授与機関識別子Scheme kakenhi
学位授与機関名 琉球大学
言語 ja
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