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  1. 学位論文
  2. 博士論文
  3. 医学研究科
  1. 部局別インデックス
  2. 医学研究科

子宮内膜症症例におけるマイクロバイオーム解析; 腹水と卵巣嚢腫内容液にマイクロバイオームは存在するのか?

http://hdl.handle.net/20.500.12000/0002018034
http://hdl.handle.net/20.500.12000/0002018034
71d91b23-83ea-4eaf-9f8d-d8763eace285
名前 / ファイル ライセンス アクション
iken540abstract.pdf iken540abstract.pdf (743 KB)
iken540review.pdf iken540review.pdf (820 KB)
iken540text.pdf iken540text.pdf (780 KB)
Item type 琉球大学リポジトリ登録用アイテムタイプ(1)
公開日 2022-06-10
タイトル
タイトル 子宮内膜症症例におけるマイクロバイオーム解析; 腹水と卵巣嚢腫内容液にマイクロバイオームは存在するのか?
言語 ja
作成者 大石, 杉子

× 大石, 杉子

ja 大石, 杉子

en Oishi, Sugiko

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 © 2022 The Authors
言語 en
権利情報 This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
主題
言語 en
主題Scheme Other
主題 16S rRNA
言語 en
主題Scheme Other
主題 endometriosis
言語 en
主題Scheme Other
主題 microbiome
言語 en
主題Scheme Other
主題 ovarian cystic fluid
言語 en
主題Scheme Other
主題 peritoneal fluid
内容記述
内容記述タイプ Abstract
内容記述 Purpose: To investigate the relationship between the microbiome of the female genital tract and endometriosis.
Methods: This prospective cohort study included 36 women who underwent laparoscopic surgery for ovarian tumor from July 2019 to April 2020. Of them, 18 had endometriosis, and 18 did not have endometriosis. Vaginal secretions, endometrial fluid, peritoneal fluid, and ovarian cystic fluid were collected during surgery. Next-generation sequencing of bacterial 16S rRNA was performed to characterize the microbiome.
Results: Specific microbiomes were not detected in either peritoneal fluid or ovarian cystic fluid regardless of the presence or absence of endometriosis and the type of cyst. When the cutoff value of infectious bacterial abundance in the vagina was set as 64.3%, there were many cases more than a cutoff value in the endometriosis group significantly (p = 0.01). When the cutoff value of infectious bacterial abundance in the endometrium was set as 18.6%, there were many cases more than a cutoff level in the endometriosis cases significantly (p = 0.02).
Conclusion: Peritoneal fluid and ovarian cystic fluid are almost sterile, although dysbiosis may occur in the vaginal and endometrial microbiome in women with endometriosis.
言語 en
出版者
言語 ja
出版者 琉球大学
言語
言語 eng
資源タイプ
資源タイプ doctoral thesis
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1002/rmb2.12441
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 1445-5781
収録物識別子タイプ EISSN
収録物識別子 1447-0578
収録物名
言語 en
収録物名 Reproductive Medicine and Biology
書誌情報
巻 21, 号 1
学位授与番号
学位授与番号 甲第540号
学位名
学位名 博士(医学)
言語 ja
学位授与年月日
学位授与年月日 2022-03-18
学位授与機関
学位授与機関識別子
学位授与機関識別子 18001
学位授与機関識別子Scheme kakenhi
学位授与機関名
学位授与機関名 琉球大学
言語 ja
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