{"_buckets": {"deposit": "fa63a5f6-9641-4de3-9473-020ef0519f63"}, "_deposit": {"created_by": 8, "id": "2018042", "owner": "8", "owners": [8], "owners_ext": {"displayname": "ryukyu_lib", "username": null}, "pid": {"revision_id": 0, "type": "depid", "value": "2018042"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02018042", "sets": ["1642838159351", "1642838409905"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "Evaluation of circulating tumor DNA as a biomarker in pancreatic cancer with liver metastasis", "subitem_1551255648112": "en"}, {"subitem_1551255647225": "肝転移を伴う膵癌における circulating tumor DNA のバイオマーカーとしての有用性", "subitem_1551255648112": "ja"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "上里, 安範", "creatorNameLang": "ja"}, {"creatorName": "Uesato, Yasunori", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "en", "subitem_1522651041219": "© 2020 Uesato et al."}, {"subitem_1522650717957": "en", "subitem_1522651041219": "This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "Pancreatic cancer is an aggressive, solid tumor, with a grave prognosis. Despite surgical treatment in patients with pancreatic cancer, the rate of recurrence is high. In addition, although tumor biomarkers are frequently used to confirm advanced pancreatic cancer, this is not accurate and the biomarkers currently used cannot indicate prognosis. This study sought to evaluate circulating tumor DNA as a tumor biomarker to prognosticate pancreatic cancer. Patients with advanced pancreatic cancer and liver metastasis (N = 104) were included, and blood samples were collected from all patients. The mutant allele frequency was measured using amplicon-based deep sequencing on a cell-free DNA panel covering 14 genes with \u003e 240 hot spots. In patients with advanced pancreatic cancer, 50% (N = 52) had detectable ctDNA levels, with TP53 (45%, N = 47) and KRAS (42.3%, N = 44) mutations the most common. Patients with detectable circulating tumor DNA levels also had significantly worse overall survival and progression free survival than ctDNA negative patients (8.4 vs 16 months, P\u003c0.0001 for overall survival; 3.2 vs 7.9 months, P\u003c0.0001 for progression-free survival). In a multivariate analysis, ctDNA status was independently associated with overall survival and progression-free survival (HR = 3.1, 95%CI = 1.9–5.0, P\u003c0.0001; HR 2.6, 95%CI = 1.7–4.0, P\u003c0.0001, respectively). Moreover, circulating tumor DNA significantly correlated with a higher number of liver metastases, the presence of lung and/or peritoneal metastases, tumor burden, and higher carbohydrate antigen 19–9 levels. This study supports the use of circulating tumor DNA as an independent prognostic marker for advanced pancreatic cancer.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "ja", "subitem_1522300316516": "琉球大学"}, {"subitem_1522300295150": "en", "subitem_1522300316516": "University of the Ryukyus"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "eng"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "EISSN", "subitem_1522646572813": "1932-6203"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "en", "subitem_1522650091861": "PLoS ONE"}]}, "item_1617187087799": {"attribute_name": "Dissertation Number", "attribute_value_mlt": [{"subitem_1551256171004": "甲第546号"}]}, "item_1617187112279": {"attribute_name": "Degree Name", "attribute_value_mlt": [{"subitem_1551256126428": "博士(医学)", "subitem_1551256129013": "ja"}]}, "item_1617187136212": {"attribute_name": "Date Granted", "attribute_value_mlt": [{"subitem_1551256096004": "2022-03-18"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617353299429": {"attribute_name": "Relation", "attribute_value_mlt": [{"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.1371/journal.pone.0235623"}}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2022-06-15"}], "download_preview_message": "", "file_order": 0, "filename": "iken546abstract.pdf", "filesize": [{"value": "917 KB"}], "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 917000.0, "url": {"objectType": "abstract", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2018042/files/iken546abstract.pdf"}, "version_id": "a1330b2b-f8ed-4047-b228-5f1d9111fdcd"}, {"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2022-06-15"}], "download_preview_message": "", "file_order": 1, "filename": "iken546review.pdf", "filesize": [{"value": "962 KB"}], "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 962000.0, "url": {"objectType": "other", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2018042/files/iken546review.pdf"}, "version_id": "63e1b43a-2dca-4904-8972-a9cc3cf77345"}, {"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2022-06-15"}], "download_preview_message": "", "file_order": 2, "filename": "iken546text.pdf", "filesize": [{"value": "832 KB"}], "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 832000.0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2018042/files/iken546text.pdf"}, "version_id": "221386b7-95a6-4053-8efb-9f29684f7a50"}]}, "item_1617944105607": {"attribute_name": "Degree Grantor", "attribute_value_mlt": [{"subitem_1551256015892": [{"subitem_1551256027296": "18001", "subitem_1551256029891": "kakenhi"}], "subitem_1551256037922": [{"subitem_1551256042287": "琉球大学", "subitem_1551256047619": "ja"}]}]}, "item_title": "Evaluation of circulating tumor DNA as a biomarker in pancreatic cancer with liver metastasis", "item_type_id": "59", "owner": "8", "path": ["1642838159351", "1642838409905"], "permalink_uri": "http://hdl.handle.net/20.500.12000/0002018042", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-06-15"}, "publish_date": "2022-06-15", "publish_status": "0", "recid": "2018042", "relation": {}, "relation_version_is_last": true, "title": ["Evaluation of circulating tumor DNA as a biomarker in pancreatic cancer with liver metastasis"], "weko_shared_id": -1}