ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "fa63a5f6-9641-4de3-9473-020ef0519f63"}, "_deposit": {"created_by": 8, "id": "2018042", "owner": "8", "owners": [8], "owners_ext": {"displayname": "ryukyu_lib", "username": null}, "pid": {"revision_id": 0, "type": "depid", "value": "2018042"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02018042", "sets": ["1642838159351", "1642838409905"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "Evaluation of circulating tumor DNA as a biomarker in pancreatic cancer with liver metastasis", "subitem_1551255648112": "en"}, {"subitem_1551255647225": "肝転移を伴う膵癌における circulating tumor DNA のバイオマーカーとしての有用性", "subitem_1551255648112": "ja"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "上里, 安範", "creatorNameLang": "ja"}, {"creatorName": "Uesato, Yasunori", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "en", "subitem_1522651041219": "© 2020 Uesato et al."}, {"subitem_1522650717957": "en", "subitem_1522651041219": "This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "Pancreatic cancer is an aggressive, solid tumor, with a grave prognosis. Despite surgical treatment in patients with pancreatic cancer, the rate of recurrence is high. In addition, although tumor biomarkers are frequently used to confirm advanced pancreatic cancer, this is not accurate and the biomarkers currently used cannot indicate prognosis. This study sought to evaluate circulating tumor DNA as a tumor biomarker to prognosticate pancreatic cancer. Patients with advanced pancreatic cancer and liver metastasis (N = 104) were included, and blood samples were collected from all patients. The mutant allele frequency was measured using amplicon-based deep sequencing on a cell-free DNA panel covering 14 genes with \u003e 240 hot spots. In patients with advanced pancreatic cancer, 50% (N = 52) had detectable ctDNA levels, with TP53 (45%, N = 47) and KRAS (42.3%, N = 44) mutations the most common. Patients with detectable circulating tumor DNA levels also had significantly worse overall survival and progression free survival than ctDNA negative patients (8.4 vs 16 months, P\u003c0.0001 for overall survival; 3.2 vs 7.9 months, P\u003c0.0001 for progression-free survival). In a multivariate analysis, ctDNA status was independently associated with overall survival and progression-free survival (HR = 3.1, 95%CI = 1.9–5.0, P\u003c0.0001; HR 2.6, 95%CI = 1.7–4.0, P\u003c0.0001, respectively). Moreover, circulating tumor DNA significantly correlated with a higher number of liver metastases, the presence of lung and/or peritoneal metastases, tumor burden, and higher carbohydrate antigen 19–9 levels. This study supports the use of circulating tumor DNA as an independent prognostic marker for advanced pancreatic cancer.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "ja", "subitem_1522300316516": "琉球大学"}, {"subitem_1522300295150": "en", "subitem_1522300316516": "University of the Ryukyus"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "eng"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "EISSN", "subitem_1522646572813": "1932-6203"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "en", "subitem_1522650091861": "PLoS ONE"}]}, "item_1617187087799": {"attribute_name": "Dissertation Number", "attribute_value_mlt": [{"subitem_1551256171004": "甲第546号"}]}, "item_1617187112279": {"attribute_name": "Degree Name", "attribute_value_mlt": [{"subitem_1551256126428": "博士(医学)", "subitem_1551256129013": "ja"}]}, "item_1617187136212": {"attribute_name": "Date Granted", "attribute_value_mlt": [{"subitem_1551256096004": "2022-03-18"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617353299429": {"attribute_name": "Relation", "attribute_value_mlt": [{"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.1371/journal.pone.0235623"}}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2022-06-15"}], "download_preview_message": "", "file_order": 0, "filename": "iken546abstract.pdf", "filesize": [{"value": "917 KB"}], "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 917000.0, "url": {"objectType": "abstract", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2018042/files/iken546abstract.pdf"}, "version_id": "a1330b2b-f8ed-4047-b228-5f1d9111fdcd"}, {"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2022-06-15"}], "download_preview_message": "", "file_order": 1, "filename": "iken546review.pdf", "filesize": [{"value": "962 KB"}], "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 962000.0, "url": {"objectType": "other", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2018042/files/iken546review.pdf"}, "version_id": "63e1b43a-2dca-4904-8972-a9cc3cf77345"}, {"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2022-06-15"}], "download_preview_message": "", "file_order": 2, "filename": "iken546text.pdf", "filesize": [{"value": "832 KB"}], "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 832000.0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2018042/files/iken546text.pdf"}, "version_id": "221386b7-95a6-4053-8efb-9f29684f7a50"}]}, "item_1617944105607": {"attribute_name": "Degree Grantor", "attribute_value_mlt": [{"subitem_1551256015892": [{"subitem_1551256027296": "18001", "subitem_1551256029891": "kakenhi"}], "subitem_1551256037922": [{"subitem_1551256042287": "琉球大学", "subitem_1551256047619": "ja"}]}]}, "item_title": "Evaluation of circulating tumor DNA as a biomarker in pancreatic cancer with liver metastasis", "item_type_id": "59", "owner": "8", "path": ["1642838159351", "1642838409905"], "permalink_uri": "http://hdl.handle.net/20.500.12000/0002018042", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-06-15"}, "publish_date": "2022-06-15", "publish_status": "0", "recid": "2018042", "relation": {}, "relation_version_is_last": true, "title": ["Evaluation of circulating tumor DNA as a biomarker in pancreatic cancer with liver metastasis"], "weko_shared_id": -1}
  1. 学位論文
  2. 博士論文
  3. 医学研究科
  1. 部局別インデックス
  2. 医学研究科

肝転移を伴う膵癌における circulating tumor DNA のバイオマーカーとしての有用性

http://hdl.handle.net/20.500.12000/0002018042
http://hdl.handle.net/20.500.12000/0002018042
0405b10e-5663-46c1-a69d-014feb60d69c
名前 / ファイル ライセンス アクション
iken546abstract.pdf iken546abstract.pdf (917 KB)
iken546review.pdf iken546review.pdf (962 KB)
iken546text.pdf iken546text.pdf (832 KB)
Item type 琉球大学リポジトリ登録用アイテムタイプ(1)
公開日 2022-06-15
タイトル
タイトル Evaluation of circulating tumor DNA as a biomarker in pancreatic cancer with liver metastasis
言語 en
タイトル
タイトル 肝転移を伴う膵癌における circulating tumor DNA のバイオマーカーとしての有用性
言語 ja
作成者 上里, 安範

× 上里, 安範

ja 上里, 安範

en Uesato, Yasunori

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 © 2020 Uesato et al.
権利情報
言語 en
権利情報 This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
内容記述
内容記述タイプ Abstract
内容記述 Pancreatic cancer is an aggressive, solid tumor, with a grave prognosis. Despite surgical treatment in patients with pancreatic cancer, the rate of recurrence is high. In addition, although tumor biomarkers are frequently used to confirm advanced pancreatic cancer, this is not accurate and the biomarkers currently used cannot indicate prognosis. This study sought to evaluate circulating tumor DNA as a tumor biomarker to prognosticate pancreatic cancer. Patients with advanced pancreatic cancer and liver metastasis (N = 104) were included, and blood samples were collected from all patients. The mutant allele frequency was measured using amplicon-based deep sequencing on a cell-free DNA panel covering 14 genes with > 240 hot spots. In patients with advanced pancreatic cancer, 50% (N = 52) had detectable ctDNA levels, with TP53 (45%, N = 47) and KRAS (42.3%, N = 44) mutations the most common. Patients with detectable circulating tumor DNA levels also had significantly worse overall survival and progression free survival than ctDNA negative patients (8.4 vs 16 months, P<0.0001 for overall survival; 3.2 vs 7.9 months, P<0.0001 for progression-free survival). In a multivariate analysis, ctDNA status was independently associated with overall survival and progression-free survival (HR = 3.1, 95%CI = 1.9–5.0, P<0.0001; HR 2.6, 95%CI = 1.7–4.0, P<0.0001, respectively). Moreover, circulating tumor DNA significantly correlated with a higher number of liver metastases, the presence of lung and/or peritoneal metastases, tumor burden, and higher carbohydrate antigen 19–9 levels. This study supports the use of circulating tumor DNA as an independent prognostic marker for advanced pancreatic cancer.
言語 en
出版者
言語 ja
出版者 琉球大学
出版者
言語 en
出版者 University of the Ryukyus
言語
言語 eng
資源タイプ
資源タイプ doctoral thesis
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1371/journal.pone.0235623
収録物識別子
収録物識別子タイプ EISSN
収録物識別子 1932-6203
収録物名
言語 en
収録物名 PLoS ONE
学位授与番号
学位授与番号 甲第546号
学位名
学位名 博士(医学)
言語 ja
学位授与年月日
学位授与年月日 2022-03-18
学位授与機関
学位授与機関識別子 18001
学位授与機関識別子Scheme kakenhi
学位授与機関名 琉球大学
言語 ja
戻る
0
views
See details
Views

Versions

Ver.1 2022-06-15 06:26:23.624311
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3