| Item type |
琉球大学リポジトリ登録用アイテムタイプ(1) |
| 公開日 |
2023-03-10 |
| タイトル |
|
|
タイトル |
Cytokines in adipose-derived mesenchymal stem cells promote the healing of liver disease |
|
言語 |
en |
| 作成者 |
Nahar, Saifun
Nakashima, Yoshiki
Miyagi-Shiohira, Chika
Kinjo, Takao
Toyoda, Zensei
Kobayashi, Naoya
Saitoh, Issei
Watanabe, Masami
Noguchi, Hirofumi
Fujita, Jiro
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© The Author(s) 2018 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報Resource |
http://creativecommons.org/ licenses/by-nc/4.0/ |
|
権利情報 |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Cell transplantation therapy |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Cytokine |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Hepatocytes |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Liquid chromatography with tandem mass spectrometry |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Liver cirrhosis |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Adipose-derived mesenchymal stem cells |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Adipose-derived mesenchymal stem cells (ADSCs) are a treatment cell source for patients with chronic liver injury. ADSCs are characterized by being harvested from the patient’s own subcutaneous adipose tissue, a high cell yield (i.e., reduced immune rejection response), accumulation at a disease nidus, suppression of excessive immune response, production of various growth factors and cytokines, angiogenic effects, anti-apoptotic effects, and control of immune cells via cell-cell interaction. We previously showed that conditioned medium of ADSCs promoted hepatocyte proliferation and improved the liver function in a mouse model of acute liver failure. Furthermore, as found by many other groups, the administration of ADSCs improved liver tissue fibrosis in a mouse model of liver cirrhosis. A comprehensive protein expression analysis by liquid chromatography with tandem mass spectrometry showed that the various cytokines and chemokines produced by ADSCs promote the healing of liver disease. In this review, we examine the ability of expressed protein components of ADSCs to promote healing in cell therapy for liver disease. Previous studies demonstrated that ADSCs are a treatment cell source for patients with chronic liver injury. This review describes the various cytokines and chemokines produced by ADSCs that promote the healing of liver disease. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Baishideng Publishing Group Inc. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.4252/wjsc.v10.i11.146 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1948-0210 |
| 収録物名 |
|
|
収録物名 |
World Journal of Stem Cells |
|
言語 |
en |
| 書誌情報 |
巻 10,
号 11,
p. 146-159,
発行日 2018-11-26
|
WJSC-10-146.pdf (1.9 MB)
