Item type |
琉球大学リポジトリ登録用アイテムタイプ(1) |
公開日 |
2023-03-14 |
タイトル |
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タイトル |
K1 gene transformation activities in AIDS-related and classic type Kaposi’s sarcoma: Correlation with clinical presentation |
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言語 |
en |
作成者 |
Tamanaha-Nakasone, Ayumi
Uehara, Karina
Tanabe, Yasuka
Ishikawa, Haruna
Yamakawa, Natsuko
Toyoda, Zensei
Kurima, Kiyoto
Kina, Shinichiro
Tsuneki, Masayuki
Okubo, Yuko
Yamaguchi, Sayaka
Utsumi, Daisuke
Takahashi, Kenzo
Arakawa, Hirofumi
Arasaki, Akira
Kinjo, Takao
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利情報 |
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言語 |
en |
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権利情報 |
© The Author(s) 2019 |
権利情報 |
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言語 |
en |
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権利情報Resource |
http://creativecommons.org/licenses/by/4.0/ |
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権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
Kaposi’s sarcoma-associated herpesvirus (KSHV) causes both AIDS-related Kaposi’s sarcoma (KS) and classic KS, but their clinical presentations are diferent, and respective mechanisms remain to be elucidated. The KSHV K1 gene is reportedly involved in tumorigenesis through the immunoreceptor tyrosine-based activation motif (ITAM). Since we found the sequence variations in the K1 gene of KSHV isolated from AIDS-related KS and classic KS, we hypothesized that the transformation activity of the K1 gene contributes to the diferent clinical presentations. To evaluate our hypothesis, we compared the transformation activities of the K1 gene between AIDS-related KS and classic KS. We also analyzed ITAM activities and the downstream AKT and NF-κB. We found that the transformation activity of AIDS-related K1 was greater than that of classic K1, and that AIDS-related K1 induced higher ITAM activity than classic K1, causing more potent Akt and NF-κB activities. K1 downregulation by siRNA in AIDS-related K1 expressing cells induced a loss of transformation properties and decreased both Akt and NF-κB activities, suggesting a correlation between the transformation activity of K1 and ITAM signaling. Our study indicates that the increased transformation activity of AIDS-related K1 is associated with its clinical aggressiveness, whereas the weak transformation activity of classic type K1 is associated with a mild clinical presentation and spontaneous regression. The mechanism of spontaneous regression of classic KS may provide new therapeutic strategy to cancer. |
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言語 |
en |
出版者 |
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言語 |
en |
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出版者 |
Nature Research |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ |
journal article |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1038/s41598-019-42763-0 |
収録物識別子 |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2045-2322 |
収録物名 |
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言語 |
en |
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収録物名 |
Scientific Reports |
書誌情報 |
巻 9,
発行日 2019-04-23
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