| Item type |
琉球大学リポジトリ登録用アイテムタイプ(1) |
| 公開日 |
2023-03-23 |
| タイトル |
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|
タイトル |
Mieap suppresses murine intestinal tumor via its mitochondrial quality control |
|
言語 |
en |
| 作成者 |
Tsuneki, Masayuki
Nakamura, Yasuyuki
Kinjo, Takao
Nakanishi, Ruri
Arakawa, Hirofumi
|
| アクセス権 |
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|
アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0 |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Mieap, a novel p53-inducible protein, plays a key role in maintaining healthy mitochondria in various pathophysiological states. Here, we show that Mieap deficiency in Apc^Min/+ mice is strikingly associated with the malignant progression of murine intestinal tumors. To understand the role that Mieap plays in in vivo tumorigenesis, we generated Mieap heterozygous (Apc^Min/+ Mieap^+/−) and homozygous (Apc^Min/+ Mieap^−/−) Apc^Min/+ mice. Interestingly, the Apc^Min/+ mice with the Mieap^+/− and Mieap^−/− genetic background revealed remarkable shortening of the lifetime compared to Apc^Min/+ mice because of severe anemia. A substantial increase in the number and size of intestinal polyps was associated with Mieap gene deficiency. Histopathologically, intestinal tumors in the Mieapdeficient Apc^Min/+ mice clearly demonstrated advanced grades of adenomas and adenocarcinomas. We demonstrated that the significant increase in morphologically unhealthy mitochondria and trace accumulations of reactive oxygen species may be mechanisms underlying the increased malignant progression of the intestinal tumors of Mieap-deficient Apc^Min/+ mice. These findings suggest that the Mieap-regulated mitochondrial quality control plays a critical role in preventing mouse intestinal tumorigenesis. |
|
言語 |
en |
| 出版者 |
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出版者 |
Nature Research |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1038/srep12472 |
| 収録物識別子 |
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収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2045-2322 |
| 収録物名 |
|
|
収録物名 |
Scientific Reports |
|
言語 |
en |
| 書誌情報 |
巻 5,
発行日 2015-07-28
|
srep12472.pdf (7.6 MB)
