Item type |
琉球大学リポジトリ登録用アイテムタイプ(1) |
公開日 |
2023-06-20 |
タイトル |
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タイトル |
A Comprehensive Study of the Immunophenotype and its Clinicopathologic Significance in Adult T-Cell Leukemia/Lymphoma |
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言語 |
en |
作成者 |
Tamaki, Tomoko
Karube, Kennosuke
Sakihama, Shugo
Tsuruta, Yuma
Awazawa, Ryoko
Hayashi, Masaki
Nakada, Norihiro
Matsumoto, Hirofumi
Yagi, Nobutake
Ohshiro, Kazuiku
Nakazato, Iwao
Kitamura, Sakiko
Nishi, Yukiko
Miyagi, Takuya
Yamaguchi, Sayaka
Nakachi, Sawako
Morishima, Satoko
Masuzaki, Hiroaki
Takahashi, Kenzo
Fukushima, Takuya
Wada, Naoki
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利情報 |
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言語 |
en |
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権利情報 |
© 2023 THE AUTHORS. Published by Elsevier Inc. on behalf of the United States & Canadian Academy of Pathology. |
権利情報 |
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言語 |
en |
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権利情報Resource |
http://creativecommons.org/licenses/by/4.0/ |
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権利情報 |
This is an open access article under the CC BY license |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
adult T-cell leukemia/lymphoma |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
immunohistochemistry |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
morphology |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
phenotype |
内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
Adult T-cell leukemia/lymphoma (ATLL) is a mature T-cell tumor caused by human T-lymphotropic virus type 1 (HTLV-1). The typical ATLL immunophenotypes are described in the 2017 World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues (positive: CD2, CD3, CD5, CD4, and CD25; negative: CD7, CD8, and cytotoxic markers; and partially positive: CD30, CCR4, and FOXP3). However, limited studies are available on the expression of these markers, and their mutual relationship remains unknown. Furthermore, the expression status of novel markers associated with T-cell lymphomas, including Th1 markers (T-bet and CXCR3), Th2 markers (GATA3 and CCR4), T follicular helper markers (BCL6, PD1, and ICOS), and T-cell receptor (TCR) markers, and their clinicopathologic significance is unclear. In this study, we performed >20 immunohistochemical stains in 117 ATLL cases to determine the comprehensive immunophenotypic profile of ATLL, which were compared on the basis of clinicopathologic factors, including morphologic variants (pleomorphic vs anaplastic), biopsy locations, treatments, Shimoyama classification-based clinical subtype, and overall survival. CD3þ/CD4þ/CD25þ/CCR4þ was considered a typical immunophenotype of ATLL, but approximately 20% of cases did not conform to this pattern. Simultaneously, the following new findings were obtained: (1) most cases were negative for TCR-b and TCR-d (104 cases, 88.9%), indicating the usefulness of negative conversion of TCR expression to provide differentiation from other T-cell tumors; (2) the positivity of CD30 and CD15 and the negativity of FOXP3 and CD3 were significantly associated with anaplastic morphology; and (3) atypical cases, such as T follicular helper marker-positive (12 cases, 10.3%) and cytotoxic molecule-positive cases (3 cases, 2.6%), were identified. No single markers could predict the overall survival among patients with acute/lymphoma subtypes of ATLL. The results of this study illustrate the diversity of ATLL phenotypes. In Tcell tumors occurring in HTLV-1 carriers, the possibility of ATLL should not be eliminated even when the tumor exhibits an atypical phenotype, and the confirmation of HTLV-1 in the tissue is recommended. |
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言語 |
en |
出版者 |
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言語 |
en |
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出版者 |
© 2023 THE AUTHORS. Published by Elsevier Inc. on behalf of the United States & Canadian Academy of Pathology. |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ |
journal article |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.modpat.2023.100169 |
収録物識別子 |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1530-0285 |
収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0893-3952 |
収録物名 |
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言語 |
en |
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収録物名 |
Modern Pathology |
書誌情報 |
巻 36,
号 8,
p. 74-89,
発行日 2023-08
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