| Item type |
琉球大学リポジトリ登録用アイテムタイプ(1) |
| 公開日 |
2023-07-18 |
| タイトル |
|
|
タイトル |
Dermatopathic reaction of lymph nodes in HTLV-1 carriers: a spectrum of reactive and neoplastic lesions |
|
言語 |
en |
| 作成者 |
Chinen, Shigeki
Miyagi, Takuya
Murakami, Yoshiya
Takatori, Mitsuyoshi
Sakihama, Shugo
Nakazato, Iwao
Kariya, Yoshiyuki
Yamaguchi, Sayaka
Takahashi, Kenzo
Karube, Kennosuke
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2020 The Authors. Histopathology published by John Wiley & Sons Ltd. |
| 権利情報 |
|
|
言語 |
en |
|
権利情報Resource |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
権利情報 |
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
adult T cell leukaemia/lymphoma |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
dermatopathic reaction |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
human T cell leukaemia virus type 1 |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
immunophenotype, prognosis |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Aims: Dermatopathic reaction is a histopathological finding of lymph nodes that usually occurs in patients with inflammatory pruritic cutaneous lesions. However, it is sometimes seen in patients with cutaneous T cell lymphoma. Adult T cell leukaemia/lymphoma (ATLL) is a T cell malignancy caused by infection with human T cell leukaemia virus type I (HTLV-1), which is frequently accompanied by cutaneous lesions. However, the detailed clinicopathological characteristics of the dermatopathic reaction of lymph nodes in ATLL patients and HTLV-1 carriers, addressed in this study, remains to be clarified.
Methods and results: We retrospectively analysed 18 nodal lesions with dermatopathic reaction in HTLV-1 carriers. Axillary and inguinal lymph nodes were the primary affected tissues. Three cases with atypical lymphoid cell infiltration were defined as ATLL with dermatopathic reaction (ATLL-D), showing an abnormal T cell immunophenotype and T cell monoclonality. Two of the three ATLL-D patients died 14 and 7 months after diagnosis (the third case had a very short follow-up). The other 15 patients were indistinguishable from reactive lesions and were defined as HTLV-1-associated lymphadenitis with dermatopathic reaction (HAL-D). They showed an indolent clinical course, with only one case eventually transforming to aggressive disease.
Conclusions: Lymph node lesions accompanied by dermatopathic reaction in HTLV1 carriers represent a spectrum that includes reactive and neoplastic conditions. HAL-D should be distinguished from ATLL-D, especially to avoid overtreatment. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
© 2020 The Authors. Histopathology published by John Wiley & Sons Ltd. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1111/his.14102 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1365-2559 |
| 収録物名 |
|
|
収録物名 |
Histopathology |
|
言語 |
en |
| 書誌情報 |
巻 77,
号 1,
p. 133-143,
発行日 2020-03-12
|
C_No77p133.pdf (2.1 MB)
