| Item type |
琉球大学リポジトリ登録用アイテムタイプ(1) |
| 公開日 |
2024-10-16 |
| タイトル |
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|
タイトル |
Brain atrophy in normal older adult links tooth loss and diet changes to future cognitive decline |
|
言語 |
en |
| 作成者 |
Nakamura, Hiroyuki
| en |
Nakamura, Hiroyuki
Graduate School of Medicine, University of the Ryukyus
|
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Noguchi-Shinohara, Moeko
| en |
Noguchi-Shinohara, Moeko
Kanazawa University Graduate School of Medical Sciences
|
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Ishimiya-Jokaji, Mai
| en |
Ishimiya-Jokaji, Mai
Kanazawa University Graduate School of Medical Sciences
|
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Kobayashi, Yutaka
| en |
Kobayashi, Yutaka
Kanazawa University Graduate School of Medical Sciences
|
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Isa, Mikana
| en |
Isa, Mikana
Graduate School of Medicine, University of the Ryukyus
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Ide, Kentaro
| en |
Ide, Kentaro
Graduate School of Medicine, University of the Ryukyus
|
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Kawano, Toshihiro
| en |
Kawano, Toshihiro
Graduate School of Medicine, University of the Ryukyus
|
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Kawashiri, Shuichi
| en |
Kawashiri, Shuichi
Kanazawa University Graduate School of Medical Sciences
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Uchida, Kazuhiro
Tatewaki, Yasuko
| en |
Tatewaki, Yasuko
Institute of Development, Aging and Cancer, Tohoku University
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Taki, Yasuyuki
| en |
Taki, Yasuyuki
Institute of Development, Aging and Cancer, Tohoku University
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Ohara, Tomoyuki
| en |
Ohara, Tomoyuki
Graduate School of Medical Sciences, Kyushu University
|
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Ninomiya, Toshiharu
| en |
Ninomiya, Toshiharu
Graduate School of Medical Sciences, Kyushu University
|
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Ono, Kenjiro
| en |
Ono, Kenjiro
Kanazawa University Graduate School of Medical Sciences
|
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|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| APC |
|
|
APC |
Paid |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© The Author(s) 2024 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報Resource |
http://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License. |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Several studies have found associations between poor oral health, particularly tooth loss and cognitivedecline. However, the specific brain regions affected by tooth loss and the probable causes remainunclear. We conducted a population-based longitudinal cohort study in Nakajima, Nanao City, Japan.Between 2016 and 2018, 2454 residents aged ≥60 participated, covering 92.9% of the local agedemographics. This study used comprehensive approach by combining detailed dental examinations,dietary assessments, magnetic resonance imaging (MRI) analysis, and cognitive evaluations. Toothloss, even in cognitively normal individuals, is associated with parahippocampal gyrus atrophy andincreased WMH volume, both of which are characteristics of dementia. Tooth loss was associatedwith altered dietary patterns, notably a reduction in plant-based food intake and an increase in fatty,processed food intake. This study highlights a possible preventative pathway where oral health mayplay a significant role in preventing the early neuropathological shifts associated with dementia. |
|
言語 |
en |
| 出版者 |
|
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出版者 |
Springer Nature |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 識別子 |
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|
識別子 |
https://doi.org/10.1038/s41514-024-00146-4 |
|
識別子タイプ |
DOI |
| 収録物識別子 |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2731-6068 |
| 収録物名 |
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収録物名 |
NPJ Aging |
|
言語 |
en |
| 書誌情報 |
巻 10,
号 1,
p. 1-10,
発行日 2024-03-22
|
N_No10p1.pdf (0 B)
