Item type |
デフォルトアイテムタイプ(フル)(1) |
公開日 |
2007-09-15 |
タイトル |
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タイトル |
A STUDY ON THE QUATERNARY STRUCTURE CHANGE OF HEMOGLOBIN I. INTERMEDIATE STRUCTURES IN O_2 LIGATION PROCESS |
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言語 |
en |
作成者 |
Arata, Yasuhide
Yara, Asao
新田, 保秀
屋良, 朝夫
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Conformational interaction at the interfaces between subunits are investigated on the basis of the atomic coordinates of human deoxy and human oxy Hbs. Hypothetical intermediate structures are used, each of which is obtained from the procedure where one or more subunits in deoxy Hb are replaced by the corresponding O_2-liganded subunits in oxy Hb using the method of superimposition of two sets of atomic coordinates. When either α or β subunit is substituted with the corresponding subunit in oxy Hb, serious steric hindrances are produced between α_1FG 4(92)Arg and β_2C 3(37)Trp or between α_1C 6(41)Thr and β_2FG 4(97)His, all of which belong to the allosteric core affected directly by ligand binding. These steric hindrances become more serious when both α_1(α_2) and β_2 (β_1) subunits are substituted. However, no steric hindrance can be seen between subunits when the subunits in oxy Hb are substituted with the corresponding subunits in deoxy Hb. |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
紀要論文 |
出版者 |
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言語 |
ja |
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出版者 |
琉球大学教育学部 |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ |
departmental bulletin paper |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
識別子 |
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識別子 |
http://hdl.handle.net/20.500.12000/1873 |
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識別子タイプ |
HDL |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0386-5746 |
収録物識別子 |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AN10144831 |
収録物名 |
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言語 |
ja |
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収録物名 |
琉球大学教育学部紀要 第一部・第二部 |
書誌情報 |
号 34,
p. 247-257
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