{"_buckets": {"deposit": "c88e51b1-fb69-4ee1-9758-9fcd26a9cbe4"}, "_deposit": {"id": "2003984", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2003984"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02003984", "sets": ["1642838338003", "1642838407795"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "A modified version of galectin-9 induces cell cycle arrest and apoptosis of Burkitt and Hodgkin lymphoma cells", "subitem_1551255648112": "en"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Makishi, Shoko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Okudaira, Takeo", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ishikawa, Chie", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Sawada, Shigeki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Watanabe, Toshiki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Hirashima, Mitsuomi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Sunakawa, Hajime", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Mori, Naoki", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186609386": {"attribute_name": "Subject", "attribute_value_mlt": [{"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "galectin-9"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "Burkitt lymphoma"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "Hodgkin lymphoma"}, {"subitem_1522299896455": "ja", "subitem_1522300014469": "Other", "subitem_1523261968819": "NF-\u03baB"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "AP-1"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "Identification of galectin-9 as a ligand for T-cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3), expressed on Th1 cells, has established the Tim-3-galectin-9 pathway as a regulator of Th1 immunity. Whereas there is compelling evidence for the effects of galectin-9 on T-cell fate, limited information is available on the impact of galectin-9 on B lymphocytes. We found that protease-resistant galectin-9, hG9NC(null), but not galectin-1 or -8, prevented cell growth of malignant B cells such as Burkitt lymphoma (BL) and Hodgkin lymphoma (HL). \u03b2-galactoside binding was essential for galectin-9-induced cell growth suppression. hG9NC(null) induced cell cycle arrest by reducing the expression of cyclin D1, D2, B1, Cdk4, Cdc25C and c-Myc, and apoptosis by reducing the expression of XIAP, c-IAP2 and survivin. Most of these genes are regulated by nuclear factor-\u03baB (NF-\u03baB), and constitutive activation of NF-\u03baB is a common characteristic of both types of malignancies. hG9NC(null) inhibited I\u03baB\u03b1 phosphorylation, resulting in suppression of NF-\u03baB. AP-1 has also been implicated in the control of cell survival. hG9NC(null) inhibited the expression of JunD, resulting in the suppression of AP-1. Our results suggest that hG9NC(null) is a potentially suitable agent for the management of BL and HL.", "subitem_description_type": "Other"}, {"subitem_description": "\u8ad6\u6587", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "en", "subitem_1522300316516": "Blackwell Publishing"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "eng"}]}, "item_1617186783814": {"attribute_name": "Identifier", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/20.500.12000/10319"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "0007-1048"}, {"subitem_1522646500366": "NCID", "subitem_1522646572813": "AA00574570"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "en", "subitem_1522650091861": "British journal of haematology"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "594", "bibliographicPageStart": "583", "bibliographicVolumeNumber": "142"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "AM", "subitem_1600292170262": "http://purl.org/coar/version/c_ab4af688f83e57aa"}]}, "item_1617353299429": {"attribute_name": "Relation", "attribute_value_mlt": [{"subitem_1522306287251": {"subitem_1522306382014": "URI", "subitem_1522306436033": "http://www3.interscience.wiley.com/journal/120120074/abstract"}}, {"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "10.1111/j.1365-2141.2008.07229.x"}}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "BJH53.Fig.Final.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2003984/files/BJH53.Fig.Final.pdf"}, "version_id": "3bd7bb2f-48c5-42a2-849e-8bc10365d2aa"}, {"accessrole": "open_access", "download_preview_message": "", "file_order": 1, "filename": "BJH53.final.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2003984/files/BJH53.final.pdf"}, "version_id": "fdcf10a5-8fb2-4fbb-ad39-b1bda5052d94"}]}, "item_title": "A modified version of galectin-9 induces cell cycle arrest and apoptosis of Burkitt and Hodgkin lymphoma cells", "item_type_id": "15", "owner": "1", "path": ["1642838338003", "1642838407795"], "permalink_uri": "http://hdl.handle.net/20.500.12000/10319", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2009-05-28"}, "publish_date": "2009-05-28", "publish_status": "0", "recid": "2003984", "relation": {}, "relation_version_is_last": true, "title": ["A modified version of galectin-9 induces cell cycle arrest and apoptosis of Burkitt and Hodgkin lymphoma cells"], "weko_shared_id": -1}