Item type |
デフォルトアイテムタイプ(フル)(1) |
公開日 |
2009-05-28 |
タイトル |
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タイトル |
A modified version of galectin-9 induces cell cycle arrest and apoptosis of Burkitt and Hodgkin lymphoma cells |
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言語 |
en |
作成者 |
Makishi, Shoko
Okudaira, Takeo
Ishikawa, Chie
Sawada, Shigeki
Watanabe, Toshiki
Hirashima, Mitsuomi
Sunakawa, Hajime
Mori, Naoki
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
galectin-9 |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Burkitt lymphoma |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Hodgkin lymphoma |
主題 |
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言語 |
ja |
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主題Scheme |
Other |
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主題 |
NF-κB |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
AP-1 |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Identification of galectin-9 as a ligand for T-cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3), expressed on Th1 cells, has established the Tim-3-galectin-9 pathway as a regulator of Th1 immunity. Whereas there is compelling evidence for the effects of galectin-9 on T-cell fate, limited information is available on the impact of galectin-9 on B lymphocytes. We found that protease-resistant galectin-9, hG9NC(null), but not galectin-1 or -8, prevented cell growth of malignant B cells such as Burkitt lymphoma (BL) and Hodgkin lymphoma (HL). β-galactoside binding was essential for galectin-9-induced cell growth suppression. hG9NC(null) induced cell cycle arrest by reducing the expression of cyclin D1, D2, B1, Cdk4, Cdc25C and c-Myc, and apoptosis by reducing the expression of XIAP, c-IAP2 and survivin. Most of these genes are regulated by nuclear factor-κB (NF-κB), and constitutive activation of NF-κB is a common characteristic of both types of malignancies. hG9NC(null) inhibited IκBα phosphorylation, resulting in suppression of NF-κB. AP-1 has also been implicated in the control of cell survival. hG9NC(null) inhibited the expression of JunD, resulting in the suppression of AP-1. Our results suggest that hG9NC(null) is a potentially suitable agent for the management of BL and HL. |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
論文 |
出版者 |
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言語 |
en |
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出版者 |
Blackwell Publishing |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ |
journal article |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
識別子 |
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識別子 |
http://hdl.handle.net/20.500.12000/10319 |
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識別子タイプ |
HDL |
関連情報 |
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識別子タイプ |
URI |
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関連識別子 |
http://www3.interscience.wiley.com/journal/120120074/abstract |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
10.1111/j.1365-2141.2008.07229.x |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0007-1048 |
収録物識別子 |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00574570 |
収録物名 |
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言語 |
en |
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収録物名 |
British journal of haematology |
書誌情報 |
巻 142,
号 4,
p. 583-594,
発行日 2008-05
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