WEKO3
アイテム
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シグナル伝達経路の阻害による成人T細胞白血病(ATL)の治療戦略
http://hdl.handle.net/20.500.12000/9407
http://hdl.handle.net/20.500.12000/9407658208f6-d16b-4c6e-843e-7924c1480aa3
名前 / ファイル | ライセンス | アクション |
---|---|---|
mori-corrected.pdf
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Item type | デフォルトアイテムタイプ(フル)(1) | |||||||
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公開日 | 2009-03-26 | |||||||
タイトル | ||||||||
タイトル | Application of Signal Transduction Inhibition as a Therapeutic Strategy for Adult T-Cell Leukemia. | |||||||
言語 | en | |||||||
タイトル | ||||||||
タイトル | シグナル伝達経路の阻害による成人T細胞白血病(ATL)の治療戦略 | |||||||
言語 | ja | |||||||
作成者 |
Mori, Naoki
× Mori, Naoki
|
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アクセス権 | ||||||||
アクセス権 | open access | |||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
主題 | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | adult T-cell leukemia | |||||||
主題 | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | human T-cell leukemia virus type 1 | |||||||
主題 | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | signal transduction | |||||||
主題 | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | apoptosis | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | IRPC(International Research Promotion Council:国際研究振興協議会)が授与しているEminent Scientist of the Year 2007(Hematology Oncology and Medical Virology部門)の受賞研究 | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | 再掲:Recent Advances and Research Updates, 9, p.47-58, 2008 | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | 再掲:Austral-Asian Journal of Cancer, Vol.7 No.2, April 2008 | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | [Abstract]Adult T-cell leukemia (ATL) is a fatal malignancy of T lymphocytes caused by human T-cell leukemia virus type 1 (HTLV-1) infection, and remains incurable. Until recently, only a few effective therapies existed. Therefore, continued efforts to develop new therapies are needed. During the last decade, rapid progress has been made in our understanding of the molecular pathways underlying the proliferation of HTLV-1-infected T cells. The processes by which messages initiate protein synthesis, cell cycle progression, and even cell death are transmitted from the cell surface or the cytoplasm to the nucleus are broadly referred to as “signal transduction”. These multistep pathways involve a host of proteins that interact with other proteins in overlapping cascades that flow downstream in a stepwise fashion from the cell membrane to the nucleus. Inappropriate overactivation or underactivation of various components of such signaling pathways can contribute to pathological processes, such as neoplasia. Conversely, molecular and pharmacological interventions that target and attempt to reverse the aberrant state of activation can be potentially of therapeutic benefits. We review the contribution of signal transduction pathways including nuclear factor-kappa B, activator protein-1, janus kinase-signal transducer and activator of transcription, and phosphatidylinositol 3-kinase-Akt to the pathogenesis of ATL and the methods by which targeted inhibition of selected signaling pathway components has been exploited to inhibit the growth of HTLV-1-infected T cells both in vitro and in vivo. The potential translation of such strategies into effects therapies for patients with ATL may improve the poor outcome associated with this neoplasia. | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | 論文 | |||||||
出版者 | ||||||||
言語 | en | |||||||
出版者 | International Research Promotion Council | |||||||
言語 | ||||||||
言語 | eng | |||||||
資源タイプ | ||||||||
資源タイプ | journal article | |||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
出版タイプ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
識別子 | ||||||||
識別子 | http://hdl.handle.net/20.500.12000/9407 | |||||||
識別子タイプ | HDL | |||||||
収録物識別子 | ||||||||
収録物識別子タイプ | ISSN | |||||||
収録物識別子 | 0972-4699 | |||||||
収録物名 | ||||||||
言語 | en | |||||||
収録物名 | Recent Advances and Research Updates | |||||||
書誌情報 |
巻 8, 号 2, p. 277-288, 発行日 2007-10 |