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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Helicobacter pylori-Induced Interleukin-12 p40 Expression

http://hdl.handle.net/20.500.12000/14407
http://hdl.handle.net/20.500.12000/14407
f9e4debb-6cec-485b-9ddb-8e92f5cda767
名前 / ファイル ライセンス アクション
IAI01456-08R2FIG.pdf IAI01456-08R2FIG.pdf
IAI01456-08R2.pdf IAI01456-08R2.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-01-04
タイトル
タイトル Helicobacter pylori-Induced Interleukin-12 p40 Expression
言語 en
作成者 Takeshima, Eriko

× Takeshima, Eriko

en Takeshima, Eriko

Tomimori, Koh

× Tomimori, Koh

en Tomimori, Koh

Teruya, Hiromitsu

× Teruya, Hiromitsu

en Teruya, Hiromitsu

Ishikawa, Chie

× Ishikawa, Chie

en Ishikawa, Chie

Senba, Masachika

× Senba, Masachika

en Senba, Masachika

D' Ambrosio, Daniele

× D' Ambrosio, Daniele

en D' Ambrosio, Daniele

Kinjo, Fukunori

× Kinjo, Fukunori

en Kinjo, Fukunori

Mimuro, Hitomi

× Mimuro, Hitomi

en Mimuro, Hitomi

Sasakawa, Chihiro

× Sasakawa, Chihiro

en Sasakawa, Chihiro

Hirayama, Toshiya

× Hirayama, Toshiya

en Hirayama, Toshiya

Fujita, Jiro

× Fujita, Jiro

en Fujita, Jiro

Mori, Naoki

× Mori, Naoki

en Mori, Naoki

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Copyright (c) 2009, American Society for Microbiology. All Rights Reserved.
内容記述
内容記述タイプ Other
内容記述 Interleukin-12 (IL-12) is a heterodimeric cytokine produced by antigen-presenting cells that promotes the development of T-helper lymphocyte 1 (Th1). Chronic gastritis induced by Helicobacter pylori is considered a Th1-mediated process. IL-12 levels in gastric biopsy samples of H. pylori-infected patients are higher than in those of uninfected individuals, but the cellular source of IL-12 remains elusive. IL-12 staining was detected in mucosal epithelial cells, lymphocytes, and macrophages in specimens of patients with H. pylori-positive gastritis. Therefore, we investigated IL-12 p40 mRNA induction by H. pylori in gastric epithelial cells and T cells. Although cag pathogenicity island (PAI)-positive H. pylori induced IL-12 p40 mRNA expression, an isogenic mutant of the cag PAI failed to induce it in both cell types. Supernatants from H. pylori cultures and H. pylori VacA induced IL-12 p40 mRNA expression in T cells but not in epithelial cells. The activation of the IL-12 p40 promoter by H. pylori was mediated through NF-κB. The transfection of IκB kinase and NF-κB-inducing kinase dominant-negative mutants inhibited H. pylori-induced IL-12 p40 activation. Inhibitors of NF-κB, phosphatidylinositol 3-kinase, p38 mitogen-activated protein kinase, and Hsp90 suppressed H. pylori- and VacA-induced IL-12 p40 mRNA expression. The results indicate that H. pylori induces IL-12 p40 expression by the activation of NF-κB, phosphatidylinositol 3-kinase, and p38 mitogen-activated protein kinase. Hsp90 is also a crucial regulator of H. pylori-induced IL-12 p40 expression. In addition to the cag PAI, VacA might be relevant in the induction of IL-12 expression and a Th1-polarized response only in T cells.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 American Society for Microbiology
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
識別子
識別子 http://hdl.handle.net/20.500.12000/14407
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ URI
関連識別子 http://iai.asm.org/cgi/content/abstract/77/4/1337
関連識別子
識別子タイプ DOI
関連識別子 10.1128/IAI.01456-08
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0019-9567
収録物識別子タイプ NCID
収録物識別子 AA00673732
収録物名
言語 en
収録物名 Infection and immunity
書誌情報
巻 77, 号 4, p. 1337-1348
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