| Item type |
デフォルトアイテムタイプ（フル）(1) |
| 公開日 |
2020-10-07 |
| タイトル |
|
|
タイトル |
A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes |
|
言語 |
en |
| 作成者 |
Taira, Makiko
Imamura, Minako
Takahashi, Atsushi
Kamatani, Yoichiro
Yamauchi, Toshimasa
Araki, Shin-ichi
Tanaka, Nobue
van Zuydam, Natalie R.
Ahlqvist, Emma
Toyoda, Masao
Umezono, Tomoya
Kawai, Koichi
Imanishi, Masahito
Watada, Hirotaka
Suzuki, Daisuke
Maegawa, Hiroshi
Babazono, Tetsuya
Kaku, Kohei
Kawamori, Ryuzo
Groop, Leif C.
McCarth, Mark, I
Kadowaki, Takashi
Maeda, Shiro
The SUMMIT Consortium
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
Creative Commons Attribution 4.0 International |
| 権利情報 |
|
|
言語 |
en |
|
権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
https://creativecommons.org/licenses/by/4.0/ |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with type 2 diabetes. We analyzed the association of 5,768,242 single nucleotide polymorphisms (SNPs) in Japanese patients with type 2 diabetes, 2,380 nephropathy cases and 5,234 controls. We further performed GWAS for diabetic nephropathy using independent Japanese patients with type 2 diabetes, 429 cases and 358 controls and the results of these two GWAS were combined with an inverse variance meta-analysis (stage-1), followed by a de novo genotyping for the candidate SNP loci (p < 1.0 x 10^<-4>) in an independent case-control study (Stage-2; 1,213 cases and 1,298 controls). After integrating stage-1 and stage-2 data, we identified one SNP locus, significantly associated with diabetic nephropathy; rs56094641 in FTO, P = 7.74 x 10^<-10>. We further examined the association of rs56094641 with diabetic nephropathy in independent Japanese patients with type 2 diabetes (902 cases and 1,221 controls), and found that the association of this locus with diabetic nephropathy remained significant after integrating all association data (P = 7.62 x 10^<-10>). We have identified FTO locus as a novel locus for conferring susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes. |
| 内容記述 |
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|
内容記述タイプ |
Other |
|
内容記述 |
論文 |
| 出版者 |
|
|
出版者 |
Public Library of Science |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 識別子 |
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|
識別子 |
http://hdl.handle.net/20.500.12000/46886 |
|
識別子タイプ |
HDL |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1371/journal.pone.0208654 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1371/journal.pone.0208654 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1932-6203 |
| 収録物名 |
|
|
収録物名 |
PLOS ONE |
|
言語 |
en |
| 書誌情報 |
巻 13,
号 12,
発行日 2018-12-19
|
journal.pone.0208654.pdf
