{"_buckets": {"deposit": "d5cb8530-e8ac-4476-ac1c-aea45b45b3ad"}, "_deposit": {"id": "2011104", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2011104"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02011104", "sets": ["1642838338003", "1642838407795"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes", "subitem_1551255648112": "en"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Taira, Makiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Imamura, Minako", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Takahashi, Atsushi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kamatani, Yoichiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yamauchi, Toshimasa", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Araki, Shin-ichi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Tanaka, Nobue", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "van Zuydam, Natalie R.", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ahlqvist, Emma", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Toyoda, Masao", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Umezono, Tomoya", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kawai, Koichi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Imanishi, Masahito", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Watada, Hirotaka", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Suzuki, Daisuke", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Maegawa, Hiroshi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Babazono, Tetsuya", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kaku, Kohei", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kawamori, Ryuzo", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Groop, Leif C.", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "McCarth, Mark, I", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kadowaki, Takashi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Maeda, Shiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "The SUMMIT Consortium", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "en", "subitem_1522651041219": "Creative Commons Attribution 4.0 International"}, {"subitem_1522650717957": "en", "subitem_1522650727486": "https://creativecommons.org/licenses/by/4.0/", "subitem_1522651041219": "https://creativecommons.org/licenses/by/4.0/"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with type 2 diabetes. We analyzed the association of 5,768,242 single nucleotide polymorphisms (SNPs) in Japanese patients with type 2 diabetes, 2,380 nephropathy cases and 5,234 controls. We further performed GWAS for diabetic nephropathy using independent Japanese patients with type 2 diabetes, 429 cases and 358 controls and the results of these two GWAS were combined with an inverse variance meta-analysis (stage-1), followed by a de novo genotyping for the candidate SNP loci (p \u003c 1.0 x 10^\u003c-4\u003e) in an independent case-control study (Stage-2; 1,213 cases and 1,298 controls). After integrating stage-1 and stage-2 data, we identified one SNP locus, significantly associated with diabetic nephropathy; rs56094641 in FTO, P = 7.74 x 10^\u003c-10\u003e. We further examined the association of rs56094641 with diabetic nephropathy in independent Japanese patients with type 2 diabetes (902 cases and 1,221 controls), and found that the association of this locus with diabetic nephropathy remained significant after integrating all association data (P = 7.62 x 10^\u003c-10\u003e). We have identified FTO locus as a novel locus for conferring susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.", "subitem_description_type": "Other"}, {"subitem_description": "\u8ad6\u6587", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "en", "subitem_1522300316516": "Public Library of Science"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "eng"}]}, "item_1617186783814": {"attribute_name": "Identifier", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/20.500.12000/46886"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "1932-6203"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "en", "subitem_1522650091861": "PLOS ONE"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-12-19", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "12", "bibliographicVolumeNumber": "13"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617353299429": {"attribute_name": "Relation", "attribute_value_mlt": [{"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.1371/journal.pone.0208654"}}, {"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.1371/journal.pone.0208654"}}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "journal.pone.0208654.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2011104/files/journal.pone.0208654.pdf"}, "version_id": "b764e6bc-1a97-4426-976a-c0b4b4423cc7"}]}, "item_title": "A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes", "item_type_id": "15", "owner": "1", "path": ["1642838338003", "1642838407795"], "permalink_uri": "http://hdl.handle.net/20.500.12000/46886", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2020-10-07"}, "publish_date": "2020-10-07", "publish_status": "0", "recid": "2011104", "relation": {}, "relation_version_is_last": true, "title": ["A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes"], "weko_shared_id": -1}