| Item type |
デフォルトアイテムタイプ（フル）(1) |
| 公開日 |
2020-10-13 |
| タイトル |
|
|
タイトル |
A functional SNP upstream of the beta-2 adrenergic receptor gene (ADRB2) is associated with obesity in Oceanic populations |
|
言語 |
en |
| 作成者 |
Naka, I
Hikami, K
Nakayama, K
Koga, M
Nishida, N
Kimura, R
Furusawa, T
Natsuhara, K
Yamauchi, T
Nakazawa, M
Ataka, Y
Ishida, T
Inaoka, T
Iwamoto, S
Matsumura, Y
Ohtsuka, R
Tsuchiya, N
Ohashi, J
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
Creative Commons Attribution-NonCommercial-NoDerivs 3.0 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報Resource |
https://creativecommons.org/licenses/by-nc-nd/3.0/ |
|
権利情報 |
https://creativecommons.org/licenses/by-nc-nd/3.0/ |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
beta-2 adrenergic receptor gene (ADRB2) |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
body mass index (BMI) |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
obesity |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Oceanic population |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
polymorphism |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
OBJECTIVE:Obesity is a growing health concern in the Oceanic populations. To investigate the genetic factors associated with adult obesity in the Oceanic populations, the association of single nucleotide polymorphisms (SNPs) of the beta-2 adrenergic receptor (ADRB2) gene with obesity was examined in 694 adults living in Tonga and Solomon Islands.\nRESULTS:A screening for variation in 16 Oceanic subjects detected 17 SNPs in the entire region of ADRB2, of which nine SNPs including two non-synonymous ones, rs1042713 (Arg16Gly) and rs1042714 (Gln27Glu), were further genotyped for all subjects. The rs34623097-A allele, at a SNP located upstream of ADRB2, showed the strongest association with risk for obesity in a logistic regression analysis adjusted for age, sex, and population (P=5.6 × 10^<−4>, odds ratio [OR]=2.5, 95% confidence interval [CI]=1.5–4.2). The 27Glu was also significantly associated with obesity in the single-point association analysis (P=0.013, OR=2.0, 95%CI=1.2–3.4); however, this association was no longer significant after adjustment for rs34623097 since these SNPs were in linkage disequilibrium with each other. A copy of the obesity-risk allele, rs34623097-A, led to a 1.6 kg/m^2 increase in body mass index (BMI; defined as weight in kilograms divided by height in meters squared) (P=0.0019). A luciferase reporter assay indicated that rs34623097-A reduced the transcriptional activity of the luciferase reporter gene by approximately 10% compared with rs34623097-G. An electrophoretic mobility shift assay demonstrated that rs34623097 modulated the binding affinity with nuclear factors. An evolutionary analysis implies that a G>A mutation at rs34623097 occurred in the Neandertal genome and then the rs34623097-A allele flowed into the ancestors of present-day humans.\nCONCLUSION:The present results suggest that rs34623097-A, which would lead to lower expression of ADRB2, contributes to the onset of obesity in the Oceanic populations. |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
論文 |
| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 識別子 |
|
|
識別子 |
http://hdl.handle.net/20.500.12000/46966 |
|
識別子タイプ |
HDL |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1038/ijo.2012.206 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1038/ijo.2012.206 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0307-0565 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1476-5497 |
| 収録物名 |
|
|
収録物名 |
International Journal of Obesity |
|
言語 |
en |
| 書誌情報 |
巻 37,
号 9,
p. 1204-1210,
発行日 2012-12-11
|
ijo2012206.pdf
