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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Disintegrin targeting of an α_vβ_3 integrin-over-expressing high-metastatic human osteosarcoma with echistatin inhibits cell proliferation, migration, invasion and adhesion in vitro

http://hdl.handle.net/20.500.12000/47549
http://hdl.handle.net/20.500.12000/47549
6e4e4d5c-da38-4194-8b2e-fb7871533934
名前 / ファイル ライセンス アクション
10111-154092-4-PB.pdf 10111-154092-4-PB.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-12-21
タイトル
タイトル Disintegrin targeting of an α_vβ_3 integrin-over-expressing high-metastatic human osteosarcoma with echistatin inhibits cell proliferation, migration, invasion and adhesion in vitro
言語 ja
作成者 Tome, Yasunori

× Tome, Yasunori

en Tome, Yasunori

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Kimura, Hiroaki

× Kimura, Hiroaki

en Kimura, Hiroaki

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Kiyuna, Tasuku

× Kiyuna, Tasuku

en Kiyuna, Tasuku

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Sugimoto, Naotoshi

× Sugimoto, Naotoshi

en Sugimoto, Naotoshi

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Tsuchiya, Hiroyuki

× Tsuchiya, Hiroyuki

en Tsuchiya, Hiroyuki

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Kanaya, Fuminori

× Kanaya, Fuminori

en Kanaya, Fuminori

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Bouvet, Michael

× Bouvet, Michael

en Bouvet, Michael

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Hoffman, Robert M.

× Hoffman, Robert M.

en Hoffman, Robert M.

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution 3.0
権利情報
言語 en
権利情報Resource https://creativecommons.org/licenses/by/3.0/
権利情報 https://creativecommons.org/licenses/by/3.0/
主題
言語 ja
主題Scheme Other
主題 α_v β_3 integrin
主題
言語 en
主題Scheme Other
主題 echistatin
主題
言語 en
主題Scheme Other
主題 green fluorescent protein/red fluorescent protein
主題
言語 en
主題Scheme Other
主題 osteosarcoma
主題
言語 en
主題Scheme Other
主題 metastasis
内容記述
内容記述タイプ Other
内容記述 The in vitro efficacy of the disintegrin echistatin was tested on a high-metastatic variant of 143B human osteosarcoma, 143B-LM4, which over-expresses α_vβ_3 integrin. Echistatin is an RGD cyclic peptide and an antagonist of α_vβ_3 integrin. In the present study, echistatin inhibited cell proliferation, migration, invasion, and adhesion of 143B-LM4 cells. 143B-LM4 cell proliferation decreased after treatment with echistatin in a time-dependent and dose-dependent manner (P <0.01). In vitro migration and invasion of 143B-LM4 cells were also inhibited by echistatin in a dose-dependent manner (P <0.01, respectively). Cell adhesion to vitronectin of 143B-LM4 cells was also inhibited by echistatin in a dose-dependent manner (P <0.01). These results suggest that α_vβ_3 integrin may be an effective target for osteosarcoma.
内容記述
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Impact Journals
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/47549
識別子タイプ HDL
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.18632/oncotarget.10111
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.18632/oncotarget.10111
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1949-2553
収録物名
言語 en
収録物名 Oncotarget
書誌情報
巻 7, 号 29, p. 46315-46320, 発行日 2016-06-16
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