Item type |
デフォルトアイテムタイプ(フル)(1) |
公開日 |
2021-01-29 |
タイトル |
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タイトル |
強皮症様皮膚硬化を認める難治性慢性GVHDに対し短波長紫外線照射が奏功した4症例 |
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言語 |
ja |
タイトル |
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タイトル |
Efficacy of narrowband UV-B phototherapy for pediatric restrictive sclerodermatous chronic graft-versus host dsease (GVHD) : a report of 4 cases from a single institute |
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言語 |
en |
作成者 |
浜田, 聡
宮下, 倫江
山本, 雄一
宮本, 二郎
屋冝, 孟
大城, 登喜子
浜田, 有為子
喜友名, しのぶ
新垣, 真弓
百名, 伸之
Hamada, Satoru
Miyashita, Michie
Yamamoto, Yuichi
Miyamoto, Jiro
Yagi, Takeshi
Oshiro, Tokiko
Hamada, Yuiko
Kiyuna, Shinobu
Arakaki, Mayumi
Hyakuna, Nobuyuki
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利情報 |
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言語 |
ja |
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権利情報 |
© 2016 日本小児血液・がん学会 |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
sclerodermatous graft-versus-host disease |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
narrowband UV-B |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
joint contracture |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Sclerodermatous GVHD is a late effect of hematopoietic stem cell transplantation, which results in the impairment of the quality of a survivor’s life, and is difficult to manage. Most cases are often steroid-refractory and steroid-dependent sclerodermatous GVHD, and secondary treatment sometimes has limited efficacy. We performed a retrospective study on four sclerodermatous GVHD patients presenting severe joint contracture treated with narrow-band ultraviolet B (NB-UVB) from July 2012 to May 2015. All the patients had sclerodermatous grade 2 or higher according to the National Institutes of Health (NIH) grading, and showed less than 70% in the performance scale (PS). Three patients received steroid therapy, namely, two patients with steroid-refractory and one patient with steroiddependent sclerodermatous GVHD. The remaining patient had a high possibility of acute myeloid leukemia relapse, favoring less immunosuppressant administration. We evaluated the responses of the patients with a photographic range of motion according to the NIH therapeutic response criteria. The observation period after irradiation was 718 days (range: 368–1039 days). A mean cumulative dose of 75 J/cm^2 (range: 51–221 J/cm^2 ) was applied in a mean number of 69 irradiations (range 53–159). All the patients showed improvement in the range of motion. The PS score was improved from a mean of 40% (pretreatment) to 75% (post-treatment). In western countries, extracorporeal photopheresis (ECP) is the mainstream secondary treatment for sclerodermatous GVHD, and its clinical trial is in progress in Japan. ECP is a promising treatment; however, there are a few problems, such as its high cost and facility accessibility in local areas. Therefore, NB-UVB can be an encouraging alternative to ECP for sclerodermatous GVHD. |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
論文 |
出版者 |
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言語 |
ja |
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出版者 |
日本小児血液・がん学会 |
言語 |
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言語 |
jpn |
資源タイプ |
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資源タイプ |
journal article |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
識別子 |
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識別子 |
http://hdl.handle.net/20.500.12000/47686 |
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識別子タイプ |
HDL |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.11412/jspho.53.453 |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.11412/jspho.53.453 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2189-5384 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2187-011X |
収録物名 |
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言語 |
ja |
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収録物名 |
日本小児血液・がん学会雑誌 |
書誌情報 |
巻 53,
号 5,
p. 453-458,
発行日 2016
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