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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

強皮症様皮膚硬化を認める難治性慢性GVHDに対し短波長紫外線照射が奏功した4症例

http://hdl.handle.net/20.500.12000/47686
http://hdl.handle.net/20.500.12000/47686
380d6db2-6c54-4e4f-87b8-c84770a88b60
名前 / ファイル ライセンス アクション
53_453.pdf 53_453.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2021-01-29
タイトル
タイトル 強皮症様皮膚硬化を認める難治性慢性GVHDに対し短波長紫外線照射が奏功した4症例
言語 ja
作成者 浜田, 聡

× 浜田, 聡

ja 浜田, 聡

宮下, 倫江

× 宮下, 倫江

ja 宮下, 倫江

山本, 雄一

× 山本, 雄一

ja 山本, 雄一

宮本, 二郎

× 宮本, 二郎

ja 宮本, 二郎

屋冝, 孟

× 屋冝, 孟

ja 屋冝, 孟

大城, 登喜子

× 大城, 登喜子

ja 大城, 登喜子

浜田, 有為子

× 浜田, 有為子

ja 浜田, 有為子

喜友名, しのぶ

× 喜友名, しのぶ

ja 喜友名, しのぶ

新垣, 真弓

× 新垣, 真弓

ja 新垣, 真弓

百名, 伸之

× 百名, 伸之

ja 百名, 伸之

Hamada, Satoru

× Hamada, Satoru

en Hamada, Satoru

Miyashita, Michie

× Miyashita, Michie

en Miyashita, Michie

Yamamoto, Yuichi

× Yamamoto, Yuichi

en Yamamoto, Yuichi

Miyamoto, Jiro

× Miyamoto, Jiro

en Miyamoto, Jiro

Yagi, Takeshi

× Yagi, Takeshi

en Yagi, Takeshi

Oshiro, Tokiko

× Oshiro, Tokiko

en Oshiro, Tokiko

Hamada, Yuiko

× Hamada, Yuiko

en Hamada, Yuiko

Kiyuna, Shinobu

× Kiyuna, Shinobu

en Kiyuna, Shinobu

Arakaki, Mayumi

× Arakaki, Mayumi

en Arakaki, Mayumi

Hyakuna, Nobuyuki

× Hyakuna, Nobuyuki

en Hyakuna, Nobuyuki

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 © 2016 日本小児血液・がん学会
主題
言語 en
主題Scheme Other
主題 sclerodermatous graft-versus-host disease
言語 en
主題Scheme Other
主題 narrowband UV-B
言語 en
主題Scheme Other
主題 joint contracture
内容記述
内容記述タイプ Other
内容記述 Sclerodermatous GVHD is a late effect of hematopoietic stem cell transplantation, which results in the impairment of the quality of a ­survivor’s life, and is difficult to manage. Most cases are often steroid-refractory and steroid-dependent sclerodermatous GVHD, and secondary treatment sometimes has limited efficacy. We performed a retrospective study on four sclerodermatous GVHD patients presenting severe joint contracture treated with narrow-band ultraviolet B (NB-UVB) from July 2012 to May 2015. All the patients had sclerodermatous grade 2 or higher according to the National Institutes of Health (NIH) grading, and showed less than 70% in the performance scale (PS). Three patients received steroid therapy, namely, two patients with steroid-refractory and one patient with steroiddependent sclerodermatous GVHD. The remaining patient had a high possibility of acute myeloid leukemia relapse, favoring less immuno­suppressant administration. We evaluated the responses of the patients with a photographic range of motion according to the NIH therapeutic response criteria. The observation period after irradiation was 718 days (range: 368–1039 days). A mean cumulative dose of 75 J/cm^2 (range: 51–221 J/cm^2 ) was applied in a mean number of 69 irradiations (range 53–159). All the patients showed improvement in the range of motion. The PS score was improved from a mean of 40% (pretreatment) to 75% (post-treatment). In western countries, extracorporeal photopheresis (ECP) is the mainstream secondary treatment for sclerodermatous GVHD, and its clinical trial is in progress in Japan. ECP is a promising treatment; however, there are a few problems, such as its high cost and facility accessibility in local areas. Therefore, NB-UVB can be an encouraging alternative to ECP for sclerodermatous GVHD.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 日本小児血液・がん学会
言語
言語 jpn
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/47686
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.11412/jspho.53.453
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.11412/jspho.53.453
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 2189-5384
収録物識別子タイプ ISSN
収録物識別子 2187-011X
収録物名
言語 ja
収録物名 日本小児血液・がん学会雑誌
書誌情報
巻 53, 号 5, p. 453-458
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