{"_buckets": {"deposit": "a0db4708-6f05-4565-80f1-cbf68efbc015"}, "_deposit": {"id": "2012376", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2012376"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02012376", "sets": ["1642838338003", "1642838407795"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas", "subitem_1551255648112": "en"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamagishi, Makoto", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Hori, Makoto", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Fujikawa, Dai", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ohsugi, Takeo", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Honma, Daisuke", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Adachi, Nobuaki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Katano, Harutaka", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Hishima, Tsunekazu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kobayashi, Seiichiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Nakano, Kazumi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Nakashima, Makoto", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Iwanaga, Masako", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Utsunomiya, Atae", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Tanaka, Yuetsu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Okada, Seiji", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Tsukasaki, Kunihiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Tobinai, Kensei", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Araki, Kazushi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Watanabe, Toshiki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Uchimaru, Kaoru", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "en", "subitem_1522651041219": "Creative Commons Attribution-NonCommercial-NoDerivatives 4.0"}, {"subitem_1522650717957": "en", "subitem_1522650727486": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "subitem_1522651041219": "https://creativecommons.org/licenses/by-nc-nd/4.0/"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "Although global H3K27me3 reprogramming is a hallmark of cancer, no effective therapeutic strategy for H3K27me3-high malignancies harboring EZH2(WT/WT) has yet been established. We explore epigenome and transcriptome in EZH2(WT/WT) and EZH2(WT/Mu) aggressive lymphomas and show that mutual interference and compensatory function of co-expressed EZH1 and EZH2 rearrange their own genome-wide distribution, thereby establishing restricted chromatin and gene expression signatures. Direct comparison of leading compounds introduces potency and a mechanism of action of the EZH1/2 dual inhibitor (valemetostat). The synthetic lethality is observed in all lymphoma models and primary adult T cell leukemia-lymphoma (ATL) cells. Opposing actions of EZH1/2-polycomb and SWI/SNF complexes are required for facultative heterochromatin formation. Inactivation of chromatin-associated genes (ARID1A, SMARCA4/BRG1, SMARCB1/SNF5, KDM6A/UTX, BAP1, KMT2D/MLL2) and oncovirus infection (HTLV-1, EBV) trigger EZH1/2 perturbation and H3K27me3 deposition. Our study provides the mechanism-based rationale for chemical dual targeting of EZH1/2 in cancer epigenome.", "subitem_description_type": "Other"}, {"subitem_description": "\u8ad6\u6587", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "en", "subitem_1522300316516": "Cell Press"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "eng"}]}, "item_1617186783814": {"attribute_name": "Identifier", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/20.500.12000/45873"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "2211-1247"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "en", "subitem_1522650091861": "Cell reports"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueNumber": "8", "bibliographicPageEnd": "2337", "bibliographicPageStart": "2321", "bibliographicVolumeNumber": "29"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617353299429": {"attribute_name": "Relation", "attribute_value_mlt": [{"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.1016/j.celrep.2019.10.083"}}, {"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.1016/j.celrep.2019.10.083"}}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "PIIS2211124719314056.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2012376/files/PIIS2211124719314056.pdf"}, "version_id": "9620c13f-0c2a-48f4-a316-52359dd7b931"}]}, "item_title": "Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas", "item_type_id": "15", "owner": "1", "path": ["1642838338003", "1642838407795"], "permalink_uri": "http://hdl.handle.net/20.500.12000/45873", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2020-05-22"}, "publish_date": "2020-05-22", "publish_status": "0", "recid": "2012376", "relation": {}, "relation_version_is_last": true, "title": ["Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas"], "weko_shared_id": -1}