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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas

http://hdl.handle.net/20.500.12000/45873
http://hdl.handle.net/20.500.12000/45873
dacccfe6-c47f-4d2c-80f1-32ac25e4bcad
名前 / ファイル ライセンス アクション
PIIS2211124719314056.pdf PIIS2211124719314056.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-05-22
タイトル
タイトル Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas
言語 en
作成者 Yamagishi, Makoto

× Yamagishi, Makoto

en Yamagishi, Makoto

Hori, Makoto

× Hori, Makoto

en Hori, Makoto

Fujikawa, Dai

× Fujikawa, Dai

en Fujikawa, Dai

Ohsugi, Takeo

× Ohsugi, Takeo

en Ohsugi, Takeo

Honma, Daisuke

× Honma, Daisuke

en Honma, Daisuke

Adachi, Nobuaki

× Adachi, Nobuaki

en Adachi, Nobuaki

Katano, Harutaka

× Katano, Harutaka

en Katano, Harutaka

Hishima, Tsunekazu

× Hishima, Tsunekazu

en Hishima, Tsunekazu

Kobayashi, Seiichiro

× Kobayashi, Seiichiro

en Kobayashi, Seiichiro

Nakano, Kazumi

× Nakano, Kazumi

en Nakano, Kazumi

Nakashima, Makoto

× Nakashima, Makoto

en Nakashima, Makoto

Iwanaga, Masako

× Iwanaga, Masako

en Iwanaga, Masako

Utsunomiya, Atae

× Utsunomiya, Atae

en Utsunomiya, Atae

Tanaka, Yuetsu

× Tanaka, Yuetsu

en Tanaka, Yuetsu

Okada, Seiji

× Okada, Seiji

en Okada, Seiji

Tsukasaki, Kunihiro

× Tsukasaki, Kunihiro

en Tsukasaki, Kunihiro

Tobinai, Kensei

× Tobinai, Kensei

en Tobinai, Kensei

Araki, Kazushi

× Araki, Kazushi

en Araki, Kazushi

Watanabe, Toshiki

× Watanabe, Toshiki

en Watanabe, Toshiki

Uchimaru, Kaoru

× Uchimaru, Kaoru

en Uchimaru, Kaoru

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution-NonCommercial-NoDerivatives 4.0
言語 en
権利情報Resource https://creativecommons.org/licenses/by-nc-nd/4.0/
権利情報 https://creativecommons.org/licenses/by-nc-nd/4.0/
内容記述
内容記述タイプ Other
内容記述 Although global H3K27me3 reprogramming is a hallmark of cancer, no effective therapeutic strategy for H3K27me3-high malignancies harboring EZH2(WT/WT) has yet been established. We explore epigenome and transcriptome in EZH2(WT/WT) and EZH2(WT/Mu) aggressive lymphomas and show that mutual interference and compensatory function of co-expressed EZH1 and EZH2 rearrange their own genome-wide distribution, thereby establishing restricted chromatin and gene expression signatures. Direct comparison of leading compounds introduces potency and a mechanism of action of the EZH1/2 dual inhibitor (valemetostat). The synthetic lethality is observed in all lymphoma models and primary adult T cell leukemia-lymphoma (ATL) cells. Opposing actions of EZH1/2-polycomb and SWI/SNF complexes are required for facultative heterochromatin formation. Inactivation of chromatin-associated genes (ARID1A, SMARCA4/BRG1, SMARCB1/SNF5, KDM6A/UTX, BAP1, KMT2D/MLL2) and oncovirus infection (HTLV-1, EBV) trigger EZH1/2 perturbation and H3K27me3 deposition. Our study provides the mechanism-based rationale for chemical dual targeting of EZH1/2 in cancer epigenome.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Cell Press
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/45873
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.celrep.2019.10.083
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.celrep.2019.10.083
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 2211-1247
収録物名
言語 en
収録物名 Cell reports
書誌情報
巻 29, 号 8, p. 2321-2337
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