Item type |
デフォルトアイテムタイプ(フル)(1) |
公開日 |
2020-06-05 |
タイトル |
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タイトル |
The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline : possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis |
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言語 |
en |
作成者 |
Saito, Mineki
Sejima, Hiroe
Naito, Tadasuke
Ushirogawa, Hiroshi
Matsuzaki, Toshio
Matsuura, Eiji
Tanaka, Yuetsu
Nakamura, Tatsufumi
Takashima, Hiroshi
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利情報 |
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言語 |
en |
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権利情報 |
Creative Commons Attribution 4.0 |
権利情報 |
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言語 |
en |
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権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
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権利情報 |
https://creativecommons.org/licenses/by/4.0/ |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
HTLV-1 |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Tax |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
CCL1 |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
HAM/TSP |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Minocycline |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Background:Chemokine (C-C motif) ligand 1 (CCL1) is produced by activated monocytes/ macrophages and T-lymphocytes, and acts as a potent attractant for Th2 cells and a subset of T-regulatory (Treg) cells. Previous reports have indicated that CCL1 is overexpressed in adult T-cell leukemia cells, mediating an autocrine anti-apoptotic loop. Because CCL1 is also known as a potent chemoattractant that plays a major role in inflammatory processes, we investigated the role of CCL1 in the pathogenesis of human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Results:The results showed that: (1) CCL1 was preferentially expressed in HAM/TSP-derived HTLV-1-infected T-cell lines, (2) CCL1 expression was induced along with Tax expression in the Tax-inducible T-cell line JPX9, (3) transient Tax expression in an HTLV-1-negative T-cell line activated the CCL1 gene promoter, (4) plasma levels of CCL1 were significantly higher in patients with HAM/TSP than in HTLV-1-seronegative patients with multiple sclerosis and HTLV-1-infected asymptomatic healthy carriers, and (5) minocycline inhibited the production of CCL1 in HTLV-1-infected T-cell lines. Conclusions:The present results suggest that elevated CCL1 levels may be associated with the pathogenesis of HAM/TSP. Although further studies are required to determine the in vivo significance, minocycline may be considered as a potential candidate for the long-term treatment of HAM/TSP via its anti-inflammatory effects, which includes the inhibition of CCL1 expression. |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
論文 |
出版者 |
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言語 |
en |
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出版者 |
BioMed Central |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ |
journal article |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
識別子 |
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識別子 |
http://hdl.handle.net/20.500.12000/46046 |
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識別子タイプ |
HDL |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1186/s12985-017-0902-6 |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1186/s12985-017-0902-6 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1743-422X |
収録物名 |
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言語 |
en |
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収録物名 |
Virology Journal |
書誌情報 |
巻 14,
発行日 2017-12-04
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