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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline : possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis

http://hdl.handle.net/20.500.12000/46046
http://hdl.handle.net/20.500.12000/46046
47bf9d7e-0a14-434f-9c43-d55486241978
名前 / ファイル ライセンス アクション
Saito2017_Article_TheCCChemokineLigandCCL1Upregu.pdf Saito2017_Article_TheCCChemokineLigandCCL1Upregu.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-06-05
タイトル
タイトル The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline : possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis
言語 en
作成者 Saito, Mineki

× Saito, Mineki

en Saito, Mineki

Sejima, Hiroe

× Sejima, Hiroe

en Sejima, Hiroe

Naito, Tadasuke

× Naito, Tadasuke

en Naito, Tadasuke

Ushirogawa, Hiroshi

× Ushirogawa, Hiroshi

en Ushirogawa, Hiroshi

Matsuzaki, Toshio

× Matsuzaki, Toshio

en Matsuzaki, Toshio

Matsuura, Eiji

× Matsuura, Eiji

en Matsuura, Eiji

Tanaka, Yuetsu

× Tanaka, Yuetsu

en Tanaka, Yuetsu

Nakamura, Tatsufumi

× Nakamura, Tatsufumi

en Nakamura, Tatsufumi

Takashima, Hiroshi

× Takashima, Hiroshi

en Takashima, Hiroshi

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution 4.0
言語 en
権利情報Resource https://creativecommons.org/licenses/by/4.0/
権利情報 https://creativecommons.org/licenses/by/4.0/
主題
言語 en
主題Scheme Other
主題 HTLV-1
言語 en
主題Scheme Other
主題 Tax
言語 en
主題Scheme Other
主題 CCL1
言語 en
主題Scheme Other
主題 HAM/TSP
言語 en
主題Scheme Other
主題 Minocycline
内容記述
内容記述タイプ Other
内容記述 Background:Chemokine (C-C motif) ligand 1 (CCL1) is produced by activated monocytes/ macrophages and T-lymphocytes, and acts as a potent attractant for Th2 cells and a subset of T-regulatory (Treg) cells. Previous reports have indicated that CCL1 is overexpressed in adult T-cell leukemia cells, mediating an autocrine anti-apoptotic loop. Because CCL1 is also known as a potent chemoattractant that plays a major role in inflammatory processes, we investigated the role of CCL1 in the pathogenesis of human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Results:The results showed that: (1) CCL1 was preferentially expressed in HAM/TSP-derived HTLV-1-infected T-cell lines, (2) CCL1 expression was induced along with Tax expression in the Tax-inducible T-cell line JPX9, (3) transient Tax expression in an HTLV-1-negative T-cell line activated the CCL1 gene promoter, (4) plasma levels of CCL1 were significantly higher in patients with HAM/TSP than in HTLV-1-seronegative patients with multiple sclerosis and HTLV-1-infected asymptomatic healthy carriers, and (5) minocycline inhibited the production of CCL1 in HTLV-1-infected T-cell lines. Conclusions:The present results suggest that elevated CCL1 levels may be associated with the pathogenesis of HAM/TSP. Although further studies are required to determine the in vivo significance, minocycline may be considered as a potential candidate for the long-term treatment of HAM/TSP via its anti-inflammatory effects, which includes the inhibition of CCL1 expression.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 BioMed Central
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/46046
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1186/s12985-017-0902-6
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1186/s12985-017-0902-6
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1743-422X
収録物名
言語 en
収録物名 Virology Journal
書誌情報
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