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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球大学医学会雑誌
  4. 6巻2号
  1. 部局別インデックス
  2. その他

[原著]毒性評価のためのマウス受精卵の In vitro 培養 : (3)桑実期胚の発育に対する制癌剤の影響

http://hdl.handle.net/20.500.12000/0002015631
http://hdl.handle.net/20.500.12000/0002015631
89ca27f8-6b56-4091-a4b1-055d8d54712e
名前 / ファイル ライセンス アクション
v6p88.pdf v6p88.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-06-30
タイトル
タイトル [原著]毒性評価のためのマウス受精卵の In vitro 培養 : (3)桑実期胚の発育に対する制癌剤の影響
言語 ja
作成者 鎌田, 紘八

× 鎌田, 紘八

ja 鎌田, 紘八

楠本, 昌子

× 楠本, 昌子

ja 楠本, 昌子

赤松, 隆

× 赤松, 隆

ja 赤松, 隆

Kamada, Kouhachi

× Kamada, Kouhachi

en Kamada, Kouhachi

Kusumoto, Masako

× Kusumoto, Masako

en Kusumoto, Masako

Akamatsu, Takashi

× Akamatsu, Takashi

en Akamatsu, Takashi

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 drug toxicity
言語 en
主題Scheme Other
主題 mutation
言語 en
主題Scheme Other
主題 morulae
言語 en
主題Scheme Other
主題 6-mercaptopurine
言語 en
主題Scheme Other
主題 vinblastin
内容記述
内容記述タイプ Other
内容記述 In mutagenicity test, culture of mouse embryo were examined to establish a shortened experimental period. The murulae stage embryo in mouse was exposed to examine effects of 6-mercaptopurine (6-MP) and vinblastin (VB) for developments. Cell counts, mitotic index and sister chromatid exchange (SCE) were determined at blastocyst stage. After exposure of 6-MP, blastocyst developed from morulae showed decrease in mitotic index with dose dependency, but no change in cell count and SCE. After the exposure of VB, mitotic index showed higher rate at 10pM or more concentrations, embryo was arrested at 1st devision in cell cycle. At lower concentrations of VB, embryo development was similar to control in cell counts, mitotic index and SCE. The mouse embryo could not be detected to elicit mutagenicity for both agents.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球大学医学部
言語
言語 jpn
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子タイプ NCID
収録物識別子 AN10027430
収録物名
言語 ja
収録物名 琉球大学医学会雑誌 : 医学部紀要 = Ryukyu medical journal
書誌情報
巻 6, 号 2, p. 88-95
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