| Item type |
デフォルトアイテムタイプ（フル）(1) |
| 公開日 |
2010-06-30 |
| タイトル |
|
|
タイトル |
[原著］ラットを用いたNeurotizationに関する実験的研究 : 第1報 |
|
言語 |
ja |
| タイトル |
|
|
タイトル |
An Experimental Study ontthe Direct Nerve Implantation in the Antenor Tibial Muscle of the Rat : 1st Report |
|
言語 |
en |
| 作成者 |
新垣, 晃
茨木, 邦夫
嘉陽, 宗俊
武内, 正典
外間, 浩
石川, 裕二
田中, 重徳
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
言語 |
ja |
|
権利情報 |
琉球医学会 |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
direct nerve implantation (neurotization) |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
motor endplate |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
newly formed endplate |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ectopic endplate |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
denervated muscle |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Relationship between newly formed endplate and original endplate in the denervated muscle after direct nerve implantation was studied in the rat. Wistar rats were divided into three groups, in group 1 (Denervation group), the common peroneal nerve was resected at the fibular head, in group 2 (Nerve repair group), the common peroneal nerve was severed at the fibular head and nerve repair was performed immediately using standard microsurgical technique, in group 3 (Neurotization group), tibial nerve was cut at the ankle level, and then the funiculus of the proximal stump of tibial nerve was splitted and implanted into the dista1 1/4 to 1/5 part of the muscle in the area there is no endplate after denervation of the anterior tibial muscle. Wet weight of the anterior tibial muscle and strength of the muscle tonically contracted by electric stimulation were measured. Histological change of the endplate and muscle was examined using acetylcholine receptor (Ach-R) stain and acetylcholine esterase (Ach-E) stain. In group 2 and 3, wet weight of the muscle and tonic contraction strength by the electric stimulation were increased beyond four weeks after the operation. Histologically, in group 1 , the original endplate was elongated following muscle atrophy without changing the principal features of the endplate. In group 2, the original endplates were almost unchanged even at 20 weeks after the operation. In group 3, the original endplates were almost normal in shape. On the other hand, ectopic endplates were found out at the neurotized sites at where there had been no original endplates. The new endplate was large and un formed and quite different from the original endplate in its shape and size. In conclusion, the mechanism of reinnervation of the denervated muscle by the direct nerve implantation was completely different from that by the nerve repair: The new endplate was formed by neurotization, whereas the original endplate was reinnervated by nerve repair. |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
論文 |
| 出版者 |
|
|
出版者 |
琉球大学医学部 |
|
言語 |
ja |
| 出版者 |
|
|
出版者 |
Faculty of Medicine, University of the Ryukyus |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0289-1530 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN10027430 |
| 収録物名 |
|
|
収録物名 |
琉球大学医学会雑誌 : 医学部紀要 = Ryukyu medical journal |
|
言語 |
ja |
| 書誌情報 |
巻 10,
号 1,
p. 27-33,
発行日 1987
|
v10p27.pdf
