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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 12巻1号
  1. 部局別インデックス
  2. その他

[原著]The Effects of Ethanol Oral Administration and Toluene Inhalation Exposure on Plasma Free Large Neutral Amino Acids in Wistar Rats

http://hdl.handle.net/20.500.12000/0002015821
http://hdl.handle.net/20.500.12000/0002015821
1491e8b2-5b28-4061-80f4-f8a816b0c96e
名前 / ファイル ライセンス アクション
v12p22.pdf v12p22.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-07-02
タイトル
タイトル [原著]The Effects of Ethanol Oral Administration and Toluene Inhalation Exposure on Plasma Free Large Neutral Amino Acids in Wistar Rats
言語 ja
作成者 Dominicus, Dalmas A. R.

× Dominicus, Dalmas A. R.

en Dominicus, Dalmas A. R.

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 ethanol
言語 en
主題Scheme Other
主題 toluene
言語 en
主題Scheme Other
主題 neutral amino acids
言語 en
主題Scheme Other
主題 branched chain amino acids
言語 en
主題Scheme Other
主題 aromatic amino acids
言語 en
主題Scheme Other
主題 behavioural changes
内容記述
内容記述タイプ Other
内容記述 To investigate the effects of ethanol or tuluene on the large neutral amino acids (LNAA) and plasma ratios tryptophan/LNAA and tyrosine/LNAA, known under physiological conditions to predict the brain concentrations of tryptophan and tyrosine respectively, a study was carried out involving Male Wistar rats divided into alcohol (ethanol) 20 rats, and toluene inhalation 20 rats, for a period of two months. Using t test ethanol oral administration caused consistent and significant increase in plasma branched chain amino acids (BCAA). Ethanol also caused a significant decrease in plasma ratio of tryptophan/LNAA. Toluene showed no effect on the BCAA as well as the plasma ratio of tryptophan/LNAA, but caused a significant increase in plasma ratio of tyrosine/LNAA. Tryptophan is the precusor of cerebral indolylamine 5-hydroxytryptamine (5-HT) , which is believed to be involved in neurotransmission and regulation of mood and possibly also certain other behaviours. Therefore the plasma amino acid characteristics observed in this study may contribute to sustaining or accentuating mood and behavioural changes seen in alcoholics. More research is needed in this area to help in varifying these findings especially in human subjects who are alcoholics or those exposed to toluene.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346888X
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 12, 号 1, p. 22-33
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