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[原著]The Effects of Ethanol Oral Administration and Toluene Inhalation Exposure on Plasma Free Large Neutral Amino Acids in Wistar Rats
http://hdl.handle.net/20.500.12000/0002015821
http://hdl.handle.net/20.500.12000/00020158211491e8b2-5b28-4061-80f4-f8a816b0c96e
名前 / ファイル | ライセンス | アクション |
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v12p22.pdf
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Item type | デフォルトアイテムタイプ(フル)(1) | |||||||
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公開日 | 2010-07-02 | |||||||
タイトル | ||||||||
タイトル | [原著]The Effects of Ethanol Oral Administration and Toluene Inhalation Exposure on Plasma Free Large Neutral Amino Acids in Wistar Rats | |||||||
言語 | ja | |||||||
作成者 |
Dominicus, Dalmas A. R.
× Dominicus, Dalmas A. R.
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アクセス権 | ||||||||
アクセス権 | open access | |||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
権利情報 | ||||||||
言語 | ja | |||||||
権利情報 | 琉球医学会 | |||||||
主題 | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | ethanol | |||||||
主題 | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | toluene | |||||||
主題 | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | neutral amino acids | |||||||
主題 | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | branched chain amino acids | |||||||
主題 | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | aromatic amino acids | |||||||
主題 | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | behavioural changes | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | To investigate the effects of ethanol or tuluene on the large neutral amino acids (LNAA) and plasma ratios tryptophan/LNAA and tyrosine/LNAA, known under physiological conditions to predict the brain concentrations of tryptophan and tyrosine respectively, a study was carried out involving Male Wistar rats divided into alcohol (ethanol) 20 rats, and toluene inhalation 20 rats, for a period of two months. Using t test ethanol oral administration caused consistent and significant increase in plasma branched chain amino acids (BCAA). Ethanol also caused a significant decrease in plasma ratio of tryptophan/LNAA. Toluene showed no effect on the BCAA as well as the plasma ratio of tryptophan/LNAA, but caused a significant increase in plasma ratio of tyrosine/LNAA. Tryptophan is the precusor of cerebral indolylamine 5-hydroxytryptamine (5-HT) , which is believed to be involved in neurotransmission and regulation of mood and possibly also certain other behaviours. Therefore the plasma amino acid characteristics observed in this study may contribute to sustaining or accentuating mood and behavioural changes seen in alcoholics. More research is needed in this area to help in varifying these findings especially in human subjects who are alcoholics or those exposed to toluene. | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | 論文 | |||||||
出版者 | ||||||||
言語 | ja | |||||||
出版者 | 琉球医学会 | |||||||
出版者 | ||||||||
言語 | en | |||||||
出版者 | Ryukyu Medical Association | |||||||
言語 | ||||||||
言語 | eng | |||||||
資源タイプ | ||||||||
資源タイプ | journal article | |||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
出版タイプ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
収録物識別子 | ||||||||
収録物識別子タイプ | ISSN | |||||||
収録物識別子 | 1346888X | |||||||
収録物識別子 | ||||||||
収録物識別子タイプ | ISSN | |||||||
収録物識別子 | 0289-1530 | |||||||
収録物識別子 | ||||||||
収録物識別子タイプ | NCID | |||||||
収録物識別子 | AN10369445 | |||||||
収録物名 | ||||||||
言語 | ja | |||||||
収録物名 | 琉球医学会誌 = Ryukyu Medical Journal | |||||||
書誌情報 |
巻 12, 号 1, p. 22-33, 発行日 1991 |