| Item type |
デフォルトアイテムタイプ（フル）(1) |
| 公開日 |
2010-07-02 |
| タイトル |
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|
タイトル |
[原著］Increased Susceptibility of B-cells in Protein-Calorie Malnutrition to Long Term Low Dose Streptozotocin and Its Effect on Re-feeding |
|
言語 |
ja |
| 作成者 |
Islam, Mohammad Rashidul
Murakami, Keiji
WakugamiTamio
Mimura, Goro
|
| アクセス権 |
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|
アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
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|
言語 |
ja |
|
権利情報 |
琉球医学会 |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Streptozotocin |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Nutrition disorders |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Islet of Langerhans |
| 主題 |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Protein-calorie malnutrition |
| 内容記述 |
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内容記述タイプ |
Other |
|
内容記述 |
The susceptibility of pancreatic B-cells of protein-calorie malnourished(PCM) rats to long term low dose streptozotocin(STZ) and the effect of this low dose STZ on refeeding were studied. Male weanling Wistar rats were fed either by 20%(30=normal) or 4%(30=PCM) protein diet. Twenty of each two groups were treated with STZ(5mg/kg/day i.m.) and the rest with buffer for one month. Ten of each STZ treated normal and PCM rats were re-fed with 20% protein diet for another one month called as RF-normal and RF-PCM respectively. Wet wt. of liver and pancreas, plasma lipids and insulin were measured. IPGTT, morphometric and histologic study of islets were done. PCM+STZ showed significantly high fasting plasma glucose (FPG) $175.9 \pm 46.6$ compared to $88.8 \pm 12.9$mg/dl ($mean \pm SD$) in normal+STZ rats. Both STZ and vehicle treated PCM rats showed impaired IPGTT with peak plasma glucose $663.4 \pm 87.8$ and $465.8 \pm 97.2$mg/dl ($mean \pm SD$) respectively. Areas under curves in case of IPGTT were significantly high in PCM with and without STZ than in normal with and without S12. These were also significantly high in normal and PCM with STZ, compared to normal and PCM without STZ. No./field and size of islet, % of B-cell area/islet and insulin levels were significantly reduced (pくO.01 vs. normal) in both STZ and vehicle treated PCM rats. Degree of reduction was more prominent in PCM+STZ. FPG remained high with $221.0 \pm 98.8$mg/dl despite some nutritional recovery in RF-PCM rats. Areas under curves in case of IPGTT were significantly high in RF-PCM than RF-normal in both before and after refeeding. The area under curve reduced significantly in RF-normal after refeeding but it was unchanged in RF-PCM rats. RF-PCM rats also showed significant reduction in morphometry and insulin level (p<0.01 vs. RF-nomal) and degree of reduction was more in RE-PCM after re-feeding. Histologic findings showed close correlationship with morphometry. We concluded that B-cel1s of morphologinIly altered islets of PCM rats were more susceptible to STZ and the effect of STZ was persistent after refeeding. These suggest the possibility of increased susceptibility of pancreatic B-cells to other B-cytotoxic influences as STZ in PCM in childhood and exposure to these agents might produce an irreversible change to the endocrine pancreas. |
| 内容記述 |
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|
内容記述タイプ |
Other |
|
内容記述 |
論文 |
| 出版者 |
|
|
出版者 |
琉球医学会 |
|
言語 |
ja |
| 出版者 |
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出版者 |
Ryukyu Medical Association |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1346888X |
| 収録物識別子 |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0289-1530 |
| 収録物識別子 |
|
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN10369445 |
| 収録物名 |
|
|
収録物名 |
琉球医学会誌 = Ryukyu Medical Journal |
|
言語 |
ja |
| 書誌情報 |
巻 12,
号 3,
p. 206-218,
発行日 1992
|
v12p206.pdf
