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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 12巻1号
  1. 部局別インデックス
  2. その他

[原著]低食塩飼育による高血圧自然発症 : ラットの中枢神経$ \alpha $_1及び$ \alpha $_2受容体の変化

http://hdl.handle.net/20.500.12000/0002015855
http://hdl.handle.net/20.500.12000/0002015855
2ad7690a-601a-42f4-9dc6-79d0811a09af
名前 / ファイル ライセンス アクション
v12p62.pdf v12p62.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-07-02
タイトル
タイトル [原著]低食塩飼育による高血圧自然発症 : ラットの中枢神経$ \alpha $_1及び$ \alpha $_2受容体の変化
言語 ja
作成者 砂川, 長彦

× 砂川, 長彦

ja 砂川, 長彦

戸沢, 雅彦

× 戸沢, 雅彦

ja 戸沢, 雅彦

瀧下, 修一

× 瀧下, 修一

ja 瀧下, 修一

柊山, 幸志郎

× 柊山, 幸志郎

ja 柊山, 幸志郎

Sunagawa, Osahiko

× Sunagawa, Osahiko

en Sunagawa, Osahiko

Tozawa, Masahiko

× Tozawa, Masahiko

en Tozawa, Masahiko

Takishita, Shuichi

× Takishita, Shuichi

en Takishita, Shuichi

Fukiyama, Koshiro

× Fukiyama, Koshiro

en Fukiyama, Koshiro

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 central $ \alpha $-adrenoceptors
言語 en
主題Scheme Other
主題 low sodium diet
言語 en
主題Scheme Other
主題 spontaneously hypertensive rats
内容記述
内容記述タイプ Other
内容記述 To clarify whether or not sodium restriction has an influence on central mechanisms of hypertension, we investigated characteristics of $ \alpha $1-and $ \alpha $2-adrenoceptors in central nervous system in SHR fed on low sodium diet. SHR and wistar-Kyoto rats (WKY) were divided into 2 groups and fed on either low sodium diet containing 0.05% sodium or normal sodium diet containing 0.4% sodium from 3 weeks of age. The experiments were performed at 6,8 and 20 weeks of age. The rat brains were divided into cortex, hypothalamus and lower brainstem. Plasma membranes were prepared, and radioligand binding studies were performed using [^3H]prazosin for $ \alpha $1-adrenoceptors and [^3H]rauwolscine for $ \alpha $2-adrenoceptors. There was no difference in body wight between low and normal sodium diet, while WKY remained normotensive. The Bmax of $ \alpha $1-adrenoceptor was increased significantly in the cortex and hypothalamus in SHR fed on normal sodium diet at 20 weeks of age and in the cortex, hypothalamus, and lower brainstem in SHR fed on low sodium diet at 8 weeks of age compared with those of respective WKY. There was no consistent change in Kd of $ \alpha $1-adrenoceptor in SHR compared with WKY. The Bmax of $ \alpha $2-adrenoceptor was increased in the cortex and hypothalamus in SHR fed on normal sodium diet at 8 weeks of age compared with WKY on the same diet and at the same age, while no increase in SHR fed on low sodium diet was observed. The Kd of $ \alpha $2-adrenoceptor was not changed consistently in SHR on either sodium diet. These results suggest that an increase in $ \alpha $1-adrenoceptor Bmax in hypothalamus might be related genetically to the initiation of hypertension in SHR.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 jpn
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346888X
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 12, 号 1, p. 62-73
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