Item type |
デフォルトアイテムタイプ(フル)(1) |
公開日 |
2010-07-02 |
タイトル |
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タイトル |
[原著]低食塩飼育による高血圧自然発症 : ラットの中枢神経$ \alpha $_1及び$ \alpha $_2受容体の変化 |
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言語 |
ja |
タイトル |
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タイトル |
Central $ \alpha $_1-and $ \alpha $_2-Adrenoceptors in Spontaneously Hypertensive Rats Fed on Low Sodium Diet from Weanling. |
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言語 |
en |
作成者 |
砂川, 長彦
戸沢, 雅彦
瀧下, 修一
柊山, 幸志郎
Sunagawa, Osahiko
Tozawa, Masahiko
Takishita, Shuichi
Fukiyama, Koshiro
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利情報 |
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言語 |
ja |
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権利情報 |
琉球医学会 |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
central $ \alpha $-adrenoceptors |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
low sodium diet |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
spontaneously hypertensive rats |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
To clarify whether or not sodium restriction has an influence on central mechanisms of hypertension, we investigated characteristics of $ \alpha $1-and $ \alpha $2-adrenoceptors in central nervous system in SHR fed on low sodium diet. SHR and wistar-Kyoto rats (WKY) were divided into 2 groups and fed on either low sodium diet containing 0.05% sodium or normal sodium diet containing 0.4% sodium from 3 weeks of age. The experiments were performed at 6,8 and 20 weeks of age. The rat brains were divided into cortex, hypothalamus and lower brainstem. Plasma membranes were prepared, and radioligand binding studies were performed using [^3H]prazosin for $ \alpha $1-adrenoceptors and [^3H]rauwolscine for $ \alpha $2-adrenoceptors. There was no difference in body wight between low and normal sodium diet, while WKY remained normotensive. The Bmax of $ \alpha $1-adrenoceptor was increased significantly in the cortex and hypothalamus in SHR fed on normal sodium diet at 20 weeks of age and in the cortex, hypothalamus, and lower brainstem in SHR fed on low sodium diet at 8 weeks of age compared with those of respective WKY. There was no consistent change in Kd of $ \alpha $1-adrenoceptor in SHR compared with WKY. The Bmax of $ \alpha $2-adrenoceptor was increased in the cortex and hypothalamus in SHR fed on normal sodium diet at 8 weeks of age compared with WKY on the same diet and at the same age, while no increase in SHR fed on low sodium diet was observed. The Kd of $ \alpha $2-adrenoceptor was not changed consistently in SHR on either sodium diet. These results suggest that an increase in $ \alpha $1-adrenoceptor Bmax in hypothalamus might be related genetically to the initiation of hypertension in SHR. |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
論文 |
出版者 |
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言語 |
ja |
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出版者 |
琉球医学会 |
出版者 |
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言語 |
en |
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出版者 |
Ryukyu Medical Association |
言語 |
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言語 |
jpn |
資源タイプ |
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資源タイプ |
journal article |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1346888X |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0289-1530 |
収録物識別子 |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AN10369445 |
収録物名 |
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言語 |
ja |
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収録物名 |
琉球医学会誌 = Ryukyu Medical Journal |
書誌情報 |
巻 12,
号 1,
p. 62-73,
発行日 1991
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