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[原著]P815 Tumor Cells Express an Intrinsic Absolute Dominant Tumor Specific Transplantation Antigen (TSTA) That Functions in Immune Regulation
http://hdl.handle.net/20.500.12000/0002015874
http://hdl.handle.net/20.500.12000/0002015874fd43acc5-cec9-4fbb-8609-fbf91b8dc8cd
名前 / ファイル | ライセンス | アクション |
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Item type | デフォルトアイテムタイプ(フル)(1) | |||||||||
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公開日 | 2010-07-02 | |||||||||
タイトル | ||||||||||
タイトル | [原著]P815 Tumor Cells Express an Intrinsic Absolute Dominant Tumor Specific Transplantation Antigen (TSTA) That Functions in Immune Regulation | |||||||||
言語 | ja | |||||||||
作成者 |
Koja, Shizuo
× Koja, Shizuo
× Tanabe, MasaoJ
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アクセス権 | ||||||||||
アクセス権 | open access | |||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
権利情報 | ||||||||||
言語 | ja | |||||||||
権利情報 | 琉球医学会 | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | minor histocompatibility antigen | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | tumor specific transplantation antigen | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | cytotoxic T lymphocytes | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | bone marrow cells | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | dominant antigen | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | As we have reported^1) , Thy.^- bone marrow cells passed through nylon wool (NW-BM) augmerited the generation of cytotoxic T lymphocytes (CTL) against minor histocompatibility (mH) antigens in primary mixed lymphocyte cultures (MLC). This study showed that when DBA/2 (H-2^d) responder lymph node (LN) cells were stimulated with syngeneic P815 (H-2^d , DBA/2 origin) tumor cells in the presence of DBA/2 helper NW-BM cells, the CTL specific for the tumor specific transplantation antigen (TSTA) of P815 tumor cells were induced easily in primary cultures in vitro. We also showed that the CTL from Balb/c (H-2^d) or B10D2 (H-2^d) responder cells stimulated with DBA/2 spleen cells killed DBA/2 Con A blast cells but not P815 tumor cells. Since the CTL recognized the absolute dominant mH antigen of DBA/2 lymphoid cells according to the previous report^1) P815 tumor cells had lost this antigen. On the other hand, the CTL from Balb/c or B10D2 responder cells stimulated with allogeneic P815 tumor cells lysed P815, but not DBA/2 target cells. Thus, P815 tumor cells expressed the intrinsic absolute dominant antigen, which was absent in DBA/2 lymphoid cells. | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 論文 | |||||||||
出版者 | ||||||||||
言語 | ja | |||||||||
出版者 | 琉球医学会 | |||||||||
出版者 | ||||||||||
言語 | en | |||||||||
出版者 | Ryukyu Medical Association | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
資源タイプ | ||||||||||
資源タイプ | journal article | |||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
出版タイプ | ||||||||||
出版タイプ | VoR | |||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 1346888X | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 0289-1530 | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AN10369445 | |||||||||
収録物名 | ||||||||||
言語 | ja | |||||||||
収録物名 | 琉球医学会誌 = Ryukyu Medical Journal | |||||||||
書誌情報 |
巻 13, 号 2, p. 147-158, 発行日 1993 |