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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 15巻1号
  1. 部局別インデックス
  2. その他

[総説]本態性高血圧におけるミネラルコルチコイドの関与について

http://hdl.handle.net/20.500.12000/0002016019
http://hdl.handle.net/20.500.12000/0002016019
0266c457-cfd2-4811-ab4b-5d6f4cce6447
名前 / ファイル ライセンス アクション
v15_1p7.pdf v15_1p7.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-07-02
タイトル
タイトル [総説]本態性高血圧におけるミネラルコルチコイドの関与について
言語 ja
作成者 小宮, 一郎

× 小宮, 一郎

ja 小宮, 一郎

高須, 信行

× 高須, 信行

ja 高須, 信行

Komiya, Ichiro

× Komiya, Ichiro

en Komiya, Ichiro

Takasu, Nobuyuki

× Takasu, Nobuyuki

en Takasu, Nobuyuki

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
内容記述
内容記述タイプ Other
内容記述 Based on experiments with excess sodium, it is hypothesized that a high blood pressure is needed for renal excretion of sodium in patients with essential hypertension. The effect of a more moderate increase in dietary sodium intake on blood pressure has not been systematically studied. A possible additional role of aldosterone on blood pressure is not well studied. We used 3222 normal subjects, 741 patients with essential hypertension, 20 patients with aldosterone-producing adenoma and 10 patients with ldiopathic hyperaldosteronism to study a possible role of sodium, renal function and aldosterone on blood pressure elevation. When compared with the controls, serum sodium concentration shifted (about 2 mEq/1) to the right in patients with essential hypertension. The incidence of upper normal serum sodium (147 mEq/1 or more) was significantly higher in hypertensive patients than in normal controls. Age-related deterioration of renal function did not explain hypertension and abnormal sodium metabolism in hypertensive patients. In hypertensive patients with normal serum sodium (70-75% of total hypertensive patients) and upper normal serum sodium (10-12% of total), aldosterone correlated well with PRA, and PRA correlated well with serum sodium, whereas such correlations were not found in hypertensive patients with upper normal sodium plus elevated aldosterone/PRA ratio (9-12% of total), the finding being similar to those of APA and IHA. Serum sodium distribution pattern was different between normal subjects and patients with essential hypertension, and, as a result, upper normal sodium was frequently found in hypertensive patients. Generally employed renal function did not explain this abnormal sodium metabolism. Nine to 12% of hypertensive patients have upper normal sodium and inappropriate elevation of aldosterone (suppressed PRA and unsuppressed aldosterone). It is suggested that, if excess sodium was taken in those patients, further elevation of blood pressure is induced because of lack of compensatory mechanism for further renal excretion of sodium.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 jpn
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346888X
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 15, 号 1, p. 7-12
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