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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 17巻4号
  1. 部局別インデックス
  2. その他

[原著]Radio frequency thermal coagulation therapy for lung tumors : An experimental study

http://hdl.handle.net/20.500.12000/0002016034
http://hdl.handle.net/20.500.12000/0002016034
dd747570-8b89-4d15-b195-9f2c00400da6
名前 / ファイル ライセンス アクション
v17p203.pdf v17p203.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-07-02
タイトル
タイトル [原著]Radio frequency thermal coagulation therapy for lung tumors : An experimental study
言語 ja
作成者 Asai, Toshiharu

× Asai, Toshiharu

en Asai, Toshiharu

Tanigawa, Noboru

× Tanigawa, Noboru

en Tanigawa, Noboru

Tanabe, MasaoJ

× Tanabe, MasaoJ

en Tanabe, MasaoJ

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 Lung tumor
言語 en
主題Scheme Other
主題 Radiofrequency
言語 en
主題Scheme Other
主題 Coagulation therapy
内容記述
内容記述タイプ Other
内容記述 We developed a thermal coagulation therapy using radio frequency dielectric warming as a local therapy for lung tumors and conducted a basic study of the procedure involved. A fine needie was percutaneously inserted into the tumor and radio frequency waves emanating from the tip of the needle were converted to thermal energy, which serves to denature and necrotize the tumor cells. In order to evaluate the cytocidal effect of this method, cells of tumor tissue subjected to thermal coagulation were cultured and their morphology was evaluated histologically. Twenty-three male Japanese white rabbits weighing 2 - 3 kg were used. A cell suspension of rabbit VX-2 tumor (10^6/0.3 ml/rabbit) was injected through the ear veins of the rabbits and 70 tumors with a diameter of 2 - 3 mm exposing on the pleural surface of the lung were collected 2 weeks later and used as implanted lung tumors. For thermal coagulation, the current was supplied for lO seconds (N = 19), 20 seconds (N = 17) and 30 seconds (N = 26); while O second (N = 8) served as a control. Among the 70 tumors, 30 were used for cell culture and 40 for tissue specimens. In the culture study, cells from a single tumor were cultured and a growth curve was plotted. The number of viable cells grown following current supply fell significantly in comparison with the group with no current supply (Student's t-test, p < O.C1). There was no significant difference in viable cell count, however, among groups receiving current supply of various durations (10 seconds, 20 seconds, and 30 seconds). As for the effect on growth capacity, there was no significant difference between viable cell counts immediately after current supply and those 14 days later in groups receiving current supply for 10 seconds and 20 seconds. In the group receiving current supply for 30 seconds, viable cell count decreased significantly both immediately after current supply and 14 days later (p < 0.05). The temperature in the marginal part of the tumors was 64.8℃ on average at the time of dielectric warming. In tissue specimens, destruction of pulmonary alveolar structure accompanied by very slight emphysematous change in the pulmonary tissue surrounding the tumors was observed in 5 of40 specimens (13%). From these results, it was concluded that this could serve as a new therapeutic procedure for lung cancer tumors.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346888X
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 17, 号 4, p. 203-209
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