| Item type |
デフォルトアイテムタイプ（フル）(1) |
| 公開日 |
2010-07-02 |
| タイトル |
|
|
タイトル |
[原著］Protective effects of lidocaine in hepatic ischemia : reperfusion injury in-vivo and ex-vivo |
|
言語 |
ja |
| 作成者 |
Tomori, Hirofumi
Shiraishi, Masayuki
Muto, Yoshihiro
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
言語 |
ja |
|
権利情報 |
琉球医学会 |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
lidocaine |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
liver |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ischemia/reperfusion injury |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
in-vivo |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ex-vivo |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
We investigated the effect of lidocaine on hepatic ischemia/reperfusion (I/R) injury in the rat both in vivo (ExperimentA, groups 1 to 3) and ex vivo (Experiment B, groups 4 to 7). In Experiment A, hepatic ischemia were performed for 60 min at room temperature. In groups 1 and 2, physiological saline (group 1, n=5) or 10 mg/kg of lidocaine (group 2, n=5) was injected through the peripheral vein, before the hepatic ischemia. In group 3 (n=5), 10 mg/kg of lidocaine was injected twice at reperfusion and before hepatic ischemia. The hepatic tissue blood flowingroup 1 was lower than in group 2 or 3 at 5 min to 90 min after reperfusion. Serum transaminase level was significantly lower in group 3 compared to that in group 1 at 2 hours after reperfusion. In Experiment B, livers were removed from the rat and preserved in saline at room temperature for 60 min, followed by 120 min of reperfusion with oxygenated perfusate at 37℃. The livers were perfused with Krebs-Henseleit solution (group 4, n=5). The perfusate was supplemented with lidocaine in group 5 (n=5), 3.5×10^6 of neutrophil in group 6 (n=5), and both lidocaine and neutrophils in group 7 (n=5). The levels of GOT, GPT and LDH were all significantly lower in group 7 than in group 6. These data thus suggest that lidocaine plays a protective role in hepatic I/R injury by stabilizing both the hepatocytes and the neutrophil membrane. |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
論文 |
| 出版者 |
|
|
出版者 |
琉球医学会 |
|
言語 |
ja |
| 出版者 |
|
|
出版者 |
Ryukyu Medical Association |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1346888X |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0289-1530 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN10369445 |
| 収録物名 |
|
|
収録物名 |
琉球医学会誌 = Ryukyu Medical Journal |
|
言語 |
ja |
| 書誌情報 |
巻 19,
号 1,
p. 11-16,
発行日 1999
|
v19p11.pdf
