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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 19巻1号
  1. 部局別インデックス
  2. その他

[原著]Protective effects of lidocaine in hepatic ischemia : reperfusion injury in-vivo and ex-vivo

http://hdl.handle.net/20.500.12000/0002016073
http://hdl.handle.net/20.500.12000/0002016073
3d6a7ef1-fb20-465d-a426-f24bc200041b
名前 / ファイル ライセンス アクション
v19p11.pdf v19p11.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-07-02
タイトル
タイトル [原著]Protective effects of lidocaine in hepatic ischemia : reperfusion injury in-vivo and ex-vivo
言語 ja
作成者 Tomori, Hirofumi

× Tomori, Hirofumi

en Tomori, Hirofumi

Shiraishi, Masayuki

× Shiraishi, Masayuki

en Shiraishi, Masayuki

Muto, Yoshihiro

× Muto, Yoshihiro

en Muto, Yoshihiro

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 lidocaine
言語 en
主題Scheme Other
主題 liver
言語 en
主題Scheme Other
主題 ischemia/reperfusion injury
言語 en
主題Scheme Other
主題 in-vivo
言語 en
主題Scheme Other
主題 ex-vivo
内容記述
内容記述タイプ Other
内容記述 We investigated the effect of lidocaine on hepatic ischemia/reperfusion (I/R) injury in the rat both in vivo (ExperimentA, groups 1 to 3) and ex vivo (Experiment B, groups 4 to 7). In Experiment A, hepatic ischemia were performed for 60 min at room temperature. In groups 1 and 2, physiological saline (group 1, n=5) or 10 mg/kg of lidocaine (group 2, n=5) was injected through the peripheral vein, before the hepatic ischemia. In group 3 (n=5), 10 mg/kg of lidocaine was injected twice at reperfusion and before hepatic ischemia. The hepatic tissue blood flowingroup 1 was lower than in group 2 or 3 at 5 min to 90 min after reperfusion. Serum transaminase level was significantly lower in group 3 compared to that in group 1 at 2 hours after reperfusion. In Experiment B, livers were removed from the rat and preserved in saline at room temperature for 60 min, followed by 120 min of reperfusion with oxygenated perfusate at 37℃. The livers were perfused with Krebs-Henseleit solution (group 4, n=5). The perfusate was supplemented with lidocaine in group 5 (n=5), 3.5×10^6 of neutrophil in group 6 (n=5), and both lidocaine and neutrophils in group 7 (n=5). The levels of GOT, GPT and LDH were all significantly lower in group 7 than in group 6. These data thus suggest that lidocaine plays a protective role in hepatic I/R injury by stabilizing both the hepatocytes and the neutrophil membrane.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346888X
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 19, 号 1, p. 11-16
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