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[総説]尿路結石の基礎と臨床 : シュウ酸と付き合って20年
http://hdl.handle.net/20.500.12000/0002016193
http://hdl.handle.net/20.500.12000/0002016193b9298e8b-caa5-432f-998b-b38481ff9a89
名前 / ファイル | ライセンス | アクション |
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v20p107.pdf
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Item type | デフォルトアイテムタイプ(フル)(1) | |||||||||
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公開日 | 2010-07-02 | |||||||||
タイトル | ||||||||||
タイトル | [総説]尿路結石の基礎と臨床 : シュウ酸と付き合って20年 | |||||||||
言語 | ja | |||||||||
タイトル | ||||||||||
タイトル | Two Decades of Basic Research on Calcium Oxalate Urolithiasis and its Clinical Implications | |||||||||
言語 | en | |||||||||
作成者 |
小川, 由英
× 小川, 由英
× Ogawa, Yoshihide
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アクセス権 | ||||||||||
アクセス権 | open access | |||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
権利情報 | ||||||||||
言語 | ja | |||||||||
権利情報 | 琉球医学会 | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Oxalate metabolism | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | hyperoxaluria | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | urolithiasis | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | In higher plants, oxalate is synthesized from glycolate (a major product of photorespiration) or ascorbate (a product of photosynthesis), and it regulates calcium activity through the production of an insoluble salt. Under conditions of calcium depletion, however, calcium oxalate crystals can dissolve, presumably providing calcium for plant growth and development. Soluble oxalate and calcium oxalate can inhibit the activity of sucking insects and may also provide a degree of protection against grazing animals. Therefore, oxalates are common constituents of plants and are found in the majority of plant families. Most animals are protected from oxalate toxicity by oxalate-degrading bacteria. In humans, oral intake of oxalate-containing food increases urinary oxalate excretion in three ways, i.e., direct absorption of an oxalate load, endogenous metabolism from vitamin C, and metabolism from glycolate (from glycolate itself and via xylitol or hydroxyproline). The role of the last pathway seems to be underestimated. Mild hyperoxaluria is well known to have an important influence on urinary oxalate saturation and stone formation. There area variety of factors that influence the urinary concentrations of oxalate, calcium, and other stone-related substances. In addition, there is diurnal variation in the urinary saturation of calcium oxalate. Magnesium and citrate salts have been shown to inhibit stone formation in rats, with alkaline salts being more potent. It is hard to predict the level of calcium oxalate saturation using any single parameter. Hypomagnesiuria, a high Ca/Mg ratio, and hypocitraturia were previously believed to be associated with stone formation, but these putative risk factors now seem to be less important. Since a high protein diet has been implicated in stone formation, continuous fluid intake and moderate physical exercise are essential to avoid stone recurrence in stone-formers. | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 論文 | |||||||||
出版者 | ||||||||||
言語 | ja | |||||||||
出版者 | 琉球医学会 | |||||||||
出版者 | ||||||||||
言語 | en | |||||||||
出版者 | Ryukyu Medical Association | |||||||||
言語 | ||||||||||
言語 | jpn | |||||||||
資源タイプ | ||||||||||
資源タイプ | journal article | |||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
出版タイプ | ||||||||||
出版タイプ | VoR | |||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 1346888X | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 0289-1530 | |||||||||
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収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AN10369445 | |||||||||
収録物名 | ||||||||||
言語 | ja | |||||||||
収録物名 | 琉球医学会誌 = Ryukyu Medical Journal | |||||||||
書誌情報 |
巻 20, 号 3, p. 107-115 |