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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球大学保健学医学雑誌
  4. 1巻4号
  1. 部局別インデックス
  2. その他

[原著]高気圧酸素環境下でのブレオマイシン併用による実験的研究

http://hdl.handle.net/20.500.12000/0002016291
http://hdl.handle.net/20.500.12000/0002016291
3e1872cf-84f7-4411-957b-2c56d4d263df
名前 / ファイル ライセンス アクション
v1p301.pdf v1p301.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2014-07-18
タイトル
タイトル [原著]高気圧酸素環境下でのブレオマイシン併用による実験的研究
言語 ja
作成者 有村, 徹

× 有村, 徹

ja 有村, 徹

竹中, 静広

× 竹中, 静広

ja 竹中, 静広

伊藤, 悦男

× 伊藤, 悦男

ja 伊藤, 悦男

湯佐, 祚子

× 湯佐, 祚子

ja 湯佐, 祚子

Arimura, Touru

× Arimura, Touru

en Arimura, Touru

Takenaka, Shizuhiro

× Takenaka, Shizuhiro

en Takenaka, Shizuhiro

Ito, Etsuo

× Ito, Etsuo

en Ito, Etsuo

Yusa, Toshiko

× Yusa, Toshiko

en Yusa, Toshiko

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
内容記述
内容記述タイプ Other
内容記述 Procedures: Ehrlich ascites carcinoma cells ( 5 x 10^6 cells) were transplanted subcutaneously under the right thigh skin of mice and the treatment ( combination of oxygen at high pressures-hereafter OHP-and Bleomycin-hereafter BLM-) was started one week after inoculation. We observed the antitumor effects of the treatment by means of the mean survival time of the mice and the inhibition of tumor growth. We set two transparent vinyl plastic bags in the pressure chamber which was maintained at 2 ATA pressure, and connected a rubber oxygen tube on one end of each plastic bag, then we allowed pure oxygen to flow into the bags. On the other end of each plastic bag, there was a 2 cm^2 approx hole through which the oxygen could escape. The mice were kept in plastic cages, 10 in each cage. The cages of mice then placed in the plastic bags, and the condition of the mice was observed through the pressure chamber window The experiments: The first experiment performed was on, 1)mice treated with BLM alone; and 2) mice treated with both BLM and OHP. We found that the antitumor effects were working better in the latter 2. However, we couldn't tell which of the two factors, high pressure itself, or concentrated oxygen, has dominantly enhanced the antitumor effects of BLM. Therefore, we performed another experiment; 1) BLM with air at high pressure, and 2) BLM with oxygen at atmospheric pressure. In this experiment, we found that the latter experimental condition produced better effects. Therefore, the results show that oxygen enhanced the antitumor effects of BLM more than high pressure itself. We observed the histological changes of the lungs in this experiment. Conspicuous changes in the lungs were metastatic carcinoma, athelectasis, hemorrhages and congestion. But there was no interstitial pneumonia or severe fibrosis in the lungs.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球大学保健学部
言語
言語 jpn
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0285-9270
収録物識別子タイプ NCID
収録物識別子 AN00250763
収録物名
言語 ja
収録物名 琉球大学保健学医学雑誌=Ryukyu University Journal of Health Sciences and Medicine
書誌情報
巻 1, 号 4, p. 301-309
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