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膀胱痛・骨盤痛の遺伝子治療
http://hdl.handle.net/20.500.12000/0002016881
http://hdl.handle.net/20.500.12000/0002016881ad3baaac-5f0c-4bee-abb1-29ab3ba64196
名前 / ファイル | ライセンス | アクション |
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Vol35p1.pdf
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Item type | デフォルトアイテムタイプ(フル)(1) | |||||||||
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公開日 | 2018-03-27 | |||||||||
タイトル | ||||||||||
タイトル | 膀胱痛・骨盤痛の遺伝子治療 | |||||||||
言語 | ja | |||||||||
タイトル | ||||||||||
タイトル | Gene therapy for painful bladder syndrome / interstitial cystitis | |||||||||
言語 | en | |||||||||
作成者 |
宮里, 実
× 宮里, 実
× Miyazato, Minoru
|
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アクセス権 | ||||||||||
アクセス権 | open access | |||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
権利情報 | ||||||||||
言語 | ja | |||||||||
権利情報 | 琉球医学会 | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | bladder pain | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | pelvic pain | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | herpes simplex virus | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | inhibitory neurotransmitters | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | GABA | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | Painful bladder syndrome/Interstitial cystitis (PBS/IC) is an unknown etiology, characterized by chronic pelvic pain, urinary frequency and urgency. Despite its high incidence, these symptoms in patients with PBS/IC are often very difficult to treat. In this research project, I propose a novel gene therapy using herpes simplex virus (HSV) refractory PBS/IC. By utilizing the natural biology of HSV, HSV-based vectors can deliver gene products to target organ specific sensory pathways, such as the bladder afferents. By changing gene products, numerous inhibitory neurotransmitters, such as gamma-amino butyric acid, opioids and interleukin can be delivered to the bladder afferents, which can inhibit pelvic pain, urinary frequency and urgency. Gene therapy for PBS/IC is a preclinical study in patients with PBS/IC refractory to usual treatment. The log-term objectives of this gene therapy project are to establish a safe and effective method for the treatment of chronic bladder and/or pelvic pain associated with PBS/IC. | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 論文 | |||||||||
出版者 | ||||||||||
言語 | ja | |||||||||
出版者 | 琉球医学会 | |||||||||
出版者 | ||||||||||
言語 | en | |||||||||
出版者 | Ryukyu Medical Association | |||||||||
言語 | ||||||||||
言語 | jpn | |||||||||
資源タイプ | ||||||||||
資源タイプ | journal article | |||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
出版タイプ | ||||||||||
出版タイプ | VoR | |||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 1346-888X | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AN10369445 | |||||||||
収録物名 | ||||||||||
言語 | ja | |||||||||
収録物名 | 琉球医学会誌 = Ryukyu Medical Journal | |||||||||
書誌情報 |
巻 35, 号 1-4, p. 1-6 |