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Compared to patients with PSGBS, thosewith PRGBS were more likely to have neuromuscular disease, poor performance status, risk of multidrug-resistant pathogeninfection, prior pneumonia history within 1 year, and prior penicillin use within 1 year. Among eight PRGBS isolates, multilocussequence typing revealed that five isolates were sequence type (ST) 358, two were ST3 and ST10, respectively, and oneisolate was ST1404. All PRGBS isolates belonged to the ST1/ST19/ST10 group. This study reveals clinical characteristicsof patients with PRGBS from respiratory specimens. 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呼吸器検体におけるペニシリン低感受性B群連鎖球菌の臨床的・細菌学的特徴: 症例対照研究
http://hdl.handle.net/20.500.12000/0002019519
http://hdl.handle.net/20.500.12000/000201951921573284-3f4e-41ed-b991-9d245098c053
名前 / ファイル | ライセンス | アクション |
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iken537abstract.pdf (1.2 MB)
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iken537review.pdf (151 KB)
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Item type | 琉球大学リポジトリ登録用アイテムタイプ(1) | |||||||
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公開日 | 2022-08-31 | |||||||
タイトル | ||||||||
タイトル | Clinical and bacterial features of Group B streptococci with reduced penicillin susceptibility from respiratory specimens: a case-control study | |||||||
言語 | en | |||||||
タイトル | ||||||||
タイトル | 呼吸器検体におけるペニシリン低感受性B群連鎖球菌の臨床的・細菌学的特徴: 症例対照研究 | |||||||
言語 | ja | |||||||
作成者 |
西山, 直哉
× 西山, 直哉
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アクセス権 | ||||||||
アクセス権 | open access | |||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
主題 | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Streptococcus agalactiae | |||||||
主題 | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Antimicrobial resistance | |||||||
主題 | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Respiratory | |||||||
主題 | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Penicillin | |||||||
内容記述 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | infants, elderly adults, and immunosuppressed patients. Generally, GBS is susceptible to penicillin; however, GBS withreduced penicillin susceptibility (PRGBS) has been reported. PRGBS are commonly isolated from respiratory specimens,but clinical features of patients with PRGBS remain unclear. In this case–control study, clinical features of patients withPRGBS and bacterial characteristics of these isolates from respiratory specimens were investigated. Patients with GBS atthe University of the Ryukyus Hospital between January 2017 and June 2018 were retrospectively investigated. GBS werefurther classified into penicillin-susceptible GBS (PSGBS) and PRGBS using a drug susceptibility test. Moreover, serotypes,genotypes, and drug resistance genes of PRGBS isolates were determined. In total, 362 GBS were isolated, of which 46 werecollected from respiratory specimens, which had the highest rate of PRGBS (24%). Compared to patients with PSGBS, thosewith PRGBS were more likely to have neuromuscular disease, poor performance status, risk of multidrug-resistant pathogeninfection, prior pneumonia history within 1 year, and prior penicillin use within 1 year. Among eight PRGBS isolates, multilocussequence typing revealed that five isolates were sequence type (ST) 358, two were ST3 and ST10, respectively, and oneisolate was ST1404. All PRGBS isolates belonged to the ST1/ST19/ST10 group. This study reveals clinical characteristicsof patients with PRGBS from respiratory specimens. Because invasive GBS infection cases are increasing, especially in theelderly, more attention should be paid to this infection. | |||||||
言語 | en | |||||||
出版者 | ||||||||
言語 | ja | |||||||
出版者 | 琉球大学 | |||||||
言語 | ||||||||
言語 | eng | |||||||
資源タイプ | ||||||||
資源タイプ | doctoral thesis | |||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
出版タイプ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
学位授与番号 | ||||||||
学位授与番号 | 甲第537号 | |||||||
学位名 | ||||||||
学位名 | 博士(医学) | |||||||
言語 | ja | |||||||
学位授与年月日 | ||||||||
学位授与年月日 | 2022-02-21 | |||||||
学位授与機関 | ||||||||
学位授与機関識別子 | 18001 | |||||||
学位授与機関識別子Scheme | kakenhi | |||||||
学位授与機関名 | 琉球大学 | |||||||
言語 | ja |