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アイテム
慢性腎臓病における尿中アンジオテンシノーゲンと腎細動脈リモデリングとの関連
http://hdl.handle.net/20.500.12000/0002019520
http://hdl.handle.net/20.500.12000/0002019520db89e617-bdf1-414a-ba65-dac7f9e32866
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iken544abstract.pdf (996 KB)
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iken544review.pdf (819 KB)
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| Item type | 琉球大学リポジトリ登録用アイテムタイプ(1) | |||||||
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| 公開日 | 2022-08-31 | |||||||
| タイトル | ||||||||
| タイトル | Association of Urinary Angiotensinogen with Renal Arteriolar Remodeling in Chronic Kidney Disease | |||||||
| 言語 | en | |||||||
| タイトル | ||||||||
| タイトル | 慢性腎臓病における尿中アンジオテンシノーゲンと腎細動脈リモデリングとの関連 | |||||||
| 言語 | ja | |||||||
| 作成者 |
金光, 崇史
× 金光, 崇史
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 権利情報 | ||||||||
| 言語 | en | |||||||
| 権利情報 | © 2022 Wolters Kluwer Health, Inc. All rights reserved. | |||||||
| 主題 | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | arteriolar remodeling | |||||||
| 主題 | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | chronic kidney diseas | |||||||
| 主題 | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | renal renin-angiotensin system | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Objective: Renin-angiotensin system (RAS) might be associated with arteriolar remodeling. The present study aimed to explore the hitherto unknown relationship between renal RAS and renal arteriolar remodeling and to elucidate whether altered renal RAS subsequently affects renal function in patients with chronic kidney disease (CKD). Methods: In this retrospective study, patients with various CKDs not using RAS inhibitors who underwent renal biopsy were included in cross-sectional and longitudinal analyses. Urinary angiotensinogen (UAGT) levels and wall/lumen ratio (WLR) were determined to evaluate renal RAS and renal arteriolar remodeling, respectively. The association between ln(UAGT) and ln(WLR) was cross-sectionally examined using a liner regression model. Furthermore, the association of ln(UAGT) with subsequent changes in estimated glomerular filtration rate (eGFR) per year were longitudinally examined in the largest subgroup of patients who were diagnosed with IgA nephropathy. Results: In the overall cohort (n = 54), the median age, blood pressures, eGFR, and WLR were 37 years, 120/73 mmHg, 85 ml/min per 1.73 m2, and 0.93, respectively. Ln(UAGT) was significantly and positively associated with ln(WLR) even after adjusting for classical and nonclassical clinical renal risk factors. In patients with IgA nephropathy, higher ln(UAGT) was associated with higher ln(WLR). Ln(UAGT) also tended to be associated with a greater decline in eGFR per year over a median period of 8.7 years, even after adjusting for potential confounding factors. Conclusion: In patients with CKD, renal RAS might be associated with renal arteriolar remodeling and future decline in eGFR, independent of potential risk factors. |
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| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | 琉球大学 | |||||||
| 言語 | ja | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第544号 | |||||||
| 学位名 | ||||||||
| 言語 | ja | |||||||
| 学位名 | 博士(医学) | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2022-03-18 | |||||||
| 学位授与機関 | ||||||||
| 言語 | ja | |||||||
| 学位授与機関名 | 琉球大学 | |||||||
