| Item type |
琉球大学リポジトリ登録用アイテムタイプ(1) |
| 公開日 |
2024-10-15 |
| タイトル |
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|
タイトル |
Relationships of the Surface Charge of Low-Density Lipoprotein (LDL) with the Serum LDL-Cholesterol and Atherosclerosis Levels in a Japanese Population: The DOSANCO Health Study |
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言語 |
en |
| 作成者 |
Nakamura, Koshi
| en |
Nakamura, Koshi
Graduate School of Medicine, University of the Ryukyus
Hokkaido University Faculty of Medicine
|
Search repository
Takeda, Seiji
| en |
Takeda, Seiji
Faculty of Pharmaceutical Sciences, Hokkaido University of Science
Faculty of Health Sciences, Hokkaido University
|
Search repository
Sakurai, Toshihiro
| en |
Sakurai, Toshihiro
Faculty of Health Sciences, Hokkaido University
|
Search repository
Ukawa, Shigekazu
| en |
Ukawa, Shigekazu
Hokkaido University Faculty of Medicine
Osaka Metropolitan University Graduate School of Human Life Science
|
Search repository
Okada, Emiko
| en |
Okada, Emiko
Hokkaido University Faculty of Medicine
Public Interest Incorporated Foundation, the Health Care Science Institute
|
Search repository
Nakagawa, Takafumi
Imae, Akihiro
Hui, Shu-Ping
Chiba, Hitoshi
| en |
Chiba, Hitoshi
Faculty of Health Sciences, Hokkaido University
Sapporo University of Health Sciences
|
Search repository
Tamakoshi, Akiko
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| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| APC |
|
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APC |
Paid |
| 権利情報 |
|
|
言語 |
en |
|
権利情報Resource |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
|
権利情報 |
This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License. |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
©2024 Japan Atherosclerosis Society |
| 主題 |
|
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Low-density lipoprotein |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Surface charge |
| 主題 |
|
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Zeta potential |
| 主題 |
|
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Cholesterol |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Epidemiology |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Aim: This study investigated the associations of the surface charge of low-density lipoprotein (LDL) with theserum LDL-cholesterol and atherosclerosis levels in a community-based Japanese population.
Methods: The study had a cross-sectional design and included 409 community residents aged 35-79 years whodid not take medications for dyslipidemia. The potential electric charge of LDL and the zeta potential, whichindicate the surface charge of LDL, were measured by laser Doppler microelectrophoresis. The correlations of thezeta potential of LDL (−mV) with the serum LDL-cholesterol levels (mg/dL), cardio-ankle vascular index (CAVI),and serum h igh-sensitivity C-reactive protein (hsCRP) levels (log-transformed values, mg/L) were examinedusing Pearson's correlation coefficient (r). Linear regression models were constructed to examine these associationsafter adjusting for potential confounding factors.
Results: A total of 201 subjects with correctly stored samples were included in the primary analysis for zetapotential measurement. An inverse correlation was observed between the LDL zeta potential and the serum LDLcholesterol levels (r=−0.20; p=0.004). This inverse association was observed after adjusting for sex, age, dietarycholesterol intake, smoking status, alcohol intake, body mass index, and the serum levels of the major classes offree fatty acids (standardized β=−6.94; p=0.005). However, the zeta potential of LDL showed almost noassociation with CAVI or the serum hsCRP levels. Similar patterns were observed in the 208 subjects withcompromised samples as well as all the original 409 subjects.
Conclusion: A higher electronegative surface charge of LDL was associated with lower serum LDL-cholesterollevels in the general Japanese population. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Japan Atherosclerosis Society |
|
言語 |
en |
| 出版者 |
|
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出版者 |
日本動脈硬化学会 |
|
言語 |
ja |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
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|
識別子タイプ |
DOI |
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関連識別子 |
http://doi.org/10.5551/jat.64961 |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1340-3478 |
| 収録物識別子 |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1880-3873 |
| 収録物名 |
|
|
収録物名 |
Journal of Atherosclerosis and Thrombosis |
|
言語 |
en |
| 書誌情報 |
p. 1-14,
発行日 2024-07-03
|
N_No1p1.pdf (534 KB)
