Item type |
デフォルトアイテムタイプ(フル)(1) |
公開日 |
2009-01-19 |
タイトル |
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タイトル |
Anti-adult T-cell leukemia/lymphoma effects of indole-3-carbinol |
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言語 |
en |
作成者 |
Machijima, Yoshiaki
Ishikawa, Chie
Sawada, Shigeki
Okudaira, Taeko
Uchihara, Jun-nosuke
Tanaka, Yuetsu
Taira, Naoya
Mori, Naoki
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
[Background] Adult T-cell leukemia/lymphoma (ATLL) is a malignancy derived from T cells infected with human T-cell leukemia virus type 1 (HTLV-1), and it is known to be resistant to standard anticancer therapies. Indole-3-carbinol (I3C), a naturally occurring component of Brassica vegetables such as cabbage, broccoli and Brussels sprout, is a promising chemopreventive agent as it is reported to possess antimutagenic, antitumorigenic and antiestrogenic properties in experimental studies. The aim of this study was to determine the potential anti-ATLL effects of I3C both in vitro and in vivo. |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
[Results] In the in vitro study, I3C inhibited cell viability of HTLV-1-infected T-cell lines and ATLL cells in a dose-dependent manner. Importantly, I3C did not exert any inhibitory effect on uninfected T-cell lines and normal peripheral blood mononuclear cells. I3C prevented the G1/S transition by reducing the expression of cyclin D1, cyclin D2, Cdk4 and Cdk6, and induced apoptosis by reducing the expression of XIAP, survivin and Bcl-2, and by upregulating the expression of Bak. The induced apoptosis was associated with activation of caspase-3, -8 and -9, and poly(ADP-ribose) polymerase cleavage. I3C also suppressed IkappaB-alpha phosphorylation and JunD expression, resulting in inactivation of NF-kappaB and AP-1. Inoculation of HTLV-1-infected T cells in mice with severe combined immunodeficiency resulted in tumor growth. The latter was inhibited by treatment with I3C (50 mg/kg/day orally), but not the vehicle control. |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
[Conclusion] Our preclinical data suggest that I3C could be potentially a useful chemotherapeutic agent for patients with ATLL. |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
論文 |
出版者 |
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言語 |
en |
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出版者 |
BioMed Central Ltd. |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ |
journal article |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
識別子 |
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識別子 |
http://hdl.handle.net/20.500.12000/8827 |
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識別子タイプ |
HDL |
関連情報 |
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識別子タイプ |
URI |
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関連識別子 |
http://www.retrovirology.com/content/6/1/7 |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
10.1186/1742-4690-6-7 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1742-4690 |
収録物識別子 |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA12051445 |
収録物名 |
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言語 |
en |
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収録物名 |
Retrovirology |
書誌情報 |
巻 6,
p. 7,
発行日 2009-01-16
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