{"_buckets": {"deposit": "984b9259-ea86-4323-a1a4-699f5926e9b6"}, "_deposit": {"id": "2004416", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2004416"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02004416", "sets": ["1642838338003", "1642838407795"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "Anti-adult T-cell leukemia/lymphoma effects of indole-3-carbinol", "subitem_1551255648112": "en"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Machijima, Yoshiaki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ishikawa, Chie", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Sawada, Shigeki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Okudaira, Taeko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Uchihara, Jun-nosuke", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Tanaka, Yuetsu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Taira, Naoya", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Mori, Naoki", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "[Background] Adult T-cell leukemia/lymphoma (ATLL) is a malignancy derived from T cells infected with human T-cell leukemia virus type 1 (HTLV-1), and it is known to be resistant to standard anticancer therapies. Indole-3-carbinol (I3C), a naturally occurring component of Brassica vegetables such as cabbage, broccoli and Brussels sprout, is a promising chemopreventive agent as it is reported to possess antimutagenic, antitumorigenic and antiestrogenic properties in experimental studies. The aim of this study was to determine the potential anti-ATLL effects of I3C both in vitro and in vivo.", "subitem_description_type": "Other"}, {"subitem_description": "[Results] In the in vitro study, I3C inhibited cell viability of HTLV-1-infected T-cell lines and ATLL cells in a dose-dependent manner. Importantly, I3C did not exert any inhibitory effect on uninfected T-cell lines and normal peripheral blood mononuclear cells. I3C prevented the G1/S transition by reducing the expression of cyclin D1, cyclin D2, Cdk4 and Cdk6, and induced apoptosis by reducing the expression of XIAP, survivin and Bcl-2, and by upregulating the expression of Bak. The induced apoptosis was associated with activation of caspase-3, -8 and -9, and poly(ADP-ribose) polymerase cleavage. I3C also suppressed IkappaB-alpha phosphorylation and JunD expression, resulting in inactivation of NF-kappaB and AP-1. Inoculation of HTLV-1-infected T cells in mice with severe combined immunodeficiency resulted in tumor growth. The latter was inhibited by treatment with I3C (50 mg/kg/day orally), but not the vehicle control.", "subitem_description_type": "Other"}, {"subitem_description": "[Conclusion] Our preclinical data suggest that I3C could be potentially a useful chemotherapeutic agent for patients with ATLL.", "subitem_description_type": "Other"}, {"subitem_description": "\u8ad6\u6587", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "en", "subitem_1522300316516": "BioMed Central Ltd."}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "eng"}]}, "item_1617186783814": {"attribute_name": "Identifier", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/20.500.12000/8827"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "1742-4690"}, {"subitem_1522646500366": "NCID", "subitem_1522646572813": "AA12051445"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "en", "subitem_1522650091861": "Retrovirology"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicPageStart": "7", "bibliographicVolumeNumber": "6"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "AM", "subitem_1600292170262": "http://purl.org/coar/version/c_ab4af688f83e57aa"}]}, "item_1617353299429": {"attribute_name": "Relation", "attribute_value_mlt": [{"subitem_1522306287251": {"subitem_1522306382014": "URI", "subitem_1522306436033": "http://www.retrovirology.com/content/6/1/7"}}, {"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "10.1186/1742-4690-6-7"}}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "Machijima.Fig.RV.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2004416/files/Machijima.Fig.RV.pdf"}, "version_id": "1ea52c0c-56c6-4753-9944-7df46343fa55"}, {"accessrole": "open_access", "download_preview_message": "", "file_order": 1, "filename": "msMori.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2004416/files/msMori.pdf"}, "version_id": "9b28f437-b2b2-4717-bd71-d076f2fe72ab"}]}, "item_title": "Anti-adult T-cell leukemia/lymphoma effects of indole-3-carbinol", "item_type_id": "15", "owner": "1", "path": ["1642838338003", "1642838407795"], "permalink_uri": "http://hdl.handle.net/20.500.12000/8827", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2009-01-19"}, "publish_date": "2009-01-19", "publish_status": "0", "recid": "2004416", "relation": {}, "relation_version_is_last": true, "title": ["Anti-adult T-cell leukemia/lymphoma effects of indole-3-carbinol"], "weko_shared_id": -1}