{"_buckets": {"deposit": "af08525a-7c1e-409f-a9bc-24171c287d77"}, "_deposit": {"id": "2011302", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2011302"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02011302", "sets": ["1642838338003", "1642838407795"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "Roles of GalNAc-disialyl Lactotetraosyl Antigens in Renal Cancer Cells", "subitem_1551255648112": "en"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tsuchida, Akio", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Senda, Motohiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ito, Akihiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Saito, Seiichi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kiso, Makoto", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ando, Takayuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Harduin-Lepers, Anne", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Matsuda, Akio", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Furukawa, Keiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Furukawa, Koichi", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "en", "subitem_1522651041219": "Creative Commons Attribution 4.0"}, {"subitem_1522650717957": "en", "subitem_1522650727486": "https://creativecommons.org/licenses/by/4.0/", "subitem_1522651041219": "https://creativecommons.org/licenses/by/4.0/"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "GalNAc-disialyl Lc4 (GalNAc-DSLc4) was reported as a novel antigen that associated with malignant features of renal cell cancers (RCCs). To clarify roles of GalNAc-DSLc4 in malignant properties of RCCs, we identified B4GalNAc-T2 as a responsible gene for the synthesis of GalNAc-DSLc4, and prepared stable transfectants of GalNAc-T2 cDNA using VMRC-RCW cells, resulting in the establishment of high expressants of GalNAc-DSLc4. They showed increased proliferation and invasion, and specific adhesion to laminin. In the transfectants, PI3K/Akt signals were highly activated by serum stimulation or adhesion to laminin. GalNAc-DSLc4 was co-localized in lipid rafts with integrin β1 and caveolin-1 in both immunoblotting of fractionated detergent extracts and immunocytostaining, particularly when stimulated with serum. Masking of GalNAc-DSLc4 with antibodies as well as PI3K inhibitor suppressed malignant properties of the transfectants. These results suggested that GalNAc-DSLc4 is involved in malignant properties of RCCs by forming a molecular complex with integrins in lipid rafts.", "subitem_description_type": "Other"}, {"subitem_description": "論文", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "en", "subitem_1522300316516": "Springer Nature"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "eng"}]}, "item_1617186783814": {"attribute_name": "Identifier", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/20.500.12000/47490"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "2045-2322"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "en", "subitem_1522650091861": "Scientific Reports"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-05-04", "bibliographicIssueDateType": "Issued"}, "bibliographicVolumeNumber": "8"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617353299429": {"attribute_name": "Relation", "attribute_value_mlt": [{"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.1038/s41598-018-25521-6"}}, {"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.1038/s41598-018-25521-6"}}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "s41598-018-25521-6.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2011302/files/s41598-018-25521-6.pdf"}, "version_id": "528510f0-c7d2-49d6-92a7-e46acd8283c2"}]}, "item_title": "Roles of GalNAc-disialyl Lactotetraosyl Antigens in Renal Cancer Cells", "item_type_id": "15", "owner": "1", "path": ["1642838338003", "1642838407795"], "permalink_uri": "http://hdl.handle.net/20.500.12000/47490", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2020-12-15"}, "publish_date": "2020-12-15", "publish_status": "0", "recid": "2011302", "relation": {}, "relation_version_is_last": true, "title": ["Roles of GalNAc-disialyl Lactotetraosyl Antigens in Renal Cancer Cells"], "weko_shared_id": -1}
Roles of GalNAc-disialyl Lactotetraosyl Antigens in Renal Cancer Cells
http://hdl.handle.net/20.500.12000/47490
http://hdl.handle.net/20.500.12000/47490