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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 18巻3号
  1. 部局別インデックス
  2. その他

[原著]In-situ perfusion of the liver as a stable model of cold ischemia in orthotopic liver transplantation

http://hdl.handle.net/20.500.12000/0002016083
http://hdl.handle.net/20.500.12000/0002016083
37fee940-29ff-4912-8080-86ba9a55c5fd
名前 / ファイル ライセンス アクション
v18p73.pdf v18p73.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-07-02
タイトル
タイトル [原著]In-situ perfusion of the liver as a stable model of cold ischemia in orthotopic liver transplantation
言語 ja
作成者 Shiraishi, Masayuki

× Shiraishi, Masayuki

en Shiraishi, Masayuki

Nozato, Eiji

× Nozato, Eiji

en Nozato, Eiji

Okuhama, Yukihiro

× Okuhama, Yukihiro

en Okuhama, Yukihiro

Tomori, Hirofumi

× Tomori, Hirofumi

en Tomori, Hirofumi

Higa, Takao

× Higa, Takao

en Higa, Takao

Taira, Kaoru

× Taira, Kaoru

en Taira, Kaoru

Muto, Yoshihiro

× Muto, Yoshihiro

en Muto, Yoshihiro

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 ischemia reperfusion injury
言語 en
主題Scheme Other
主題 liver
言語 en
主題Scheme Other
主題 in-situ per fusion
内容記述
内容記述タイプ Other
内容記述 Various models of hepatic ischemia/reperfusion (I/R) injury were tested, using both rats (groups 1, 2 and 3, each n=10) and pigs (groups4 and5, each n=5). To create cold ischemia for 1 hr, an orthotopic liver transplantation (OLT) was performed in groups 1 and 4 using the cuff technique to reconstruct the portal vein and infra-hepatic vein in group 1, and using the veno-venous bypass during a non-hepatic phase in group 4. In groups 3 and 5, in-situ perfusion of the liver was performed without taking out the liver under a portosystemic shunt, which was achieved by a splenic transposition (created 4 weeks prior to the surgery) in group 3, and by a pump controlled veno-venous bypass in group 5. In group 2, a simple clamp of the portal triads was applied, without flushing out the blood from the liver. The survival rate at 1 week after surgery was 90% (9/10), 70% (7/10), 100% (10/10), 60% (3/5), 100% (5/5) in groups 1 to 5, respectively. Regarding the macroscopic findings of the liver 1 week after ischemia, lobar necrosis (1 case) and patchy necrosis (3 case) were characteristically found in group 1, but not in either groups 2 or 3. The serum hepatic enzyme levels showed a large deviation from case to case in groups 1, 2, and 4, in response to the same amount of cold ischemia. However, these values were relatively uniform in groups 3 and 5, in which in-situ per fusion was performed. In conclusion, the above described in-situ perfusion model of the liver is thus considered to provide a stable in-vivo model for studying hepatic I/R injury, in both rats and pigs.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346888X
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 18, 号 3, p. 73-77
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