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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 29巻3・4号
  1. 部局別インデックス
  2. その他

[原著]HPV E6 is an H_2O_2 responsive molecule associated with IL-8 production

http://hdl.handle.net/20.500.12000/0002016240
http://hdl.handle.net/20.500.12000/0002016240
536beea7-8789-46ad-90fe-af4e634918e2
名前 / ファイル ライセンス アクション
v29(3,4)p23.pdf v29(3,4)p23.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2012-04-13
タイトル
タイトル [原著]HPV E6 is an H_2O_2 responsive molecule associated with IL-8 production
言語 ja
作成者 Takemoto, Hiroyuki

× Takemoto, Hiroyuki

en Takemoto, Hiroyuki

Kina, Shinichiro

× Kina, Shinichiro

en Kina, Shinichiro

Arakaki, Keiichi

× Arakaki, Keiichi

en Arakaki, Keiichi

Matayoshi, Akira

× Matayoshi, Akira

en Matayoshi, Akira

Liang, Feixin

× Liang, Feixin

en Liang, Feixin

Phonaphonh, Thongsavanh

× Phonaphonh, Thongsavanh

en Phonaphonh, Thongsavanh

Kuang, Hai

× Kuang, Hai

en Kuang, Hai

Sunakawa, Hajime

× Sunakawa, Hajime

en Sunakawa, Hajime

嵩元, 裕之

× 嵩元, 裕之

ja 嵩元, 裕之

喜名, 振一郎

× 喜名, 振一郎

ja 喜名, 振一郎

新垣, 敬一

× 新垣, 敬一

ja 新垣, 敬一

又吉, 亮

× 又吉, 亮

ja 又吉, 亮

砂川, 元

× 砂川, 元

ja 砂川, 元

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 HPV
言語 en
主題Scheme Other
主題 H_2O_2
言語 en
主題Scheme Other
主題 IL-8
内容記述
内容記述タイプ Other
内容記述 Angiogenesis induced by inflammation occurs in infected sites and is crucial for the initiation of cancer progression. In cervical cancer, IL-8 (Interleukin-8) production is linked to cancer progression. At inflamed sites, neutrophils deploy a potent antimicrobial arsenal, including ROS. Here, we show that a ROS (H_2O_2) activates p38 MAPK to increase the expression of IL-8 in HeLa cells (HPV18-positive cells). We found that knockdown of HPV (Human Papillomavirus) E6 inhibited H_2O_2- and MG132-induced IL-8 production in HeLa cells. These findings elucidate an interesting signaling pathway by which inflammation can induce angiogenesis to cause cervical cancer progression.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346-888X
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 29, 号 3・4, p. 23-30
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