{"_buckets": {"deposit": "2d50ef85-90c9-4951-96f6-9909fb7ed525"}, "_deposit": {"id": "2016240", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2016240"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02016240", "sets": ["1642838227236", "1642838412624"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "\uff3b\u539f\u8457\uff3dHPV E6 is an H_2O_2 responsive molecule associated with IL-8 production", "subitem_1551255648112": "ja"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Takemoto, Hiroyuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kina, Shinichiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Arakaki, Keiichi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Matayoshi, Akira", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Liang, Feixin", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Phonaphonh, Thongsavanh", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kuang, Hai", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Sunakawa, Hajime", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "\u5d69\u5143, \u88d5\u4e4b", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "\u559c\u540d, \u632f\u4e00\u90ce", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "\u65b0\u57a3, \u656c\u4e00", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "\u53c8\u5409, \u4eae", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "\u7802\u5ddd, \u5143", "creatorNameLang": "ja"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "ja", "subitem_1522651041219": "\u7409\u7403\u533b\u5b66\u4f1a"}]}, "item_1617186609386": {"attribute_name": "Subject", "attribute_value_mlt": [{"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "HPV"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "H_2O_2"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "IL-8"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "Angiogenesis induced by inflammation occurs in infected sites and is crucial for the initiation of cancer progression. In cervical cancer, IL-8 (Interleukin-8) production is linked to cancer progression. At inflamed sites, neutrophils deploy a potent antimicrobial arsenal, including ROS. Here, we show that a ROS (H_2O_2) activates p38 MAPK to increase the expression of IL-8 in HeLa cells (HPV18-positive cells). We found that knockdown of HPV (Human Papillomavirus) E6 inhibited H_2O_2- and MG132-induced IL-8 production in HeLa cells. These findings elucidate an interesting signaling pathway by which inflammation can induce angiogenesis to cause cervical cancer progression.", "subitem_description_type": "Other"}, {"subitem_description": "\u8ad6\u6587", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "ja", "subitem_1522300316516": "\u7409\u7403\u533b\u5b66\u4f1a"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "eng"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "1346-888X"}, {"subitem_1522646500366": "ISSN", "subitem_1522646572813": "0289-1530"}, {"subitem_1522646500366": "NCID", "subitem_1522646572813": "AN10369445"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "ja", "subitem_1522650091861": "\u7409\u7403\u533b\u5b66\u4f1a\u8a8c = Ryukyu Medical Journal"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueNumber": "3\uff654", "bibliographicPageEnd": "30", "bibliographicPageStart": "23", "bibliographicVolumeNumber": "29"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "v29(3,4)p23.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2016240/files/v29(3,4)p23.pdf"}, "version_id": "cc78a383-675d-456d-9f16-8acad3bdec65"}]}, "item_title": "\uff3b\u539f\u8457\uff3dHPV E6 is an H_2O_2 responsive molecule associated with IL-8 production", "item_type_id": "15", "owner": "1", "path": ["1642838227236", "1642838412624"], "permalink_uri": "http://hdl.handle.net/20.500.12000/0002016240", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2012-04-13"}, "publish_date": "2012-04-13", "publish_status": "0", "recid": "2016240", "relation": {}, "relation_version_is_last": true, "title": ["\uff3b\u539f\u8457\uff3dHPV E6 is an H_2O_2 responsive molecule associated with IL-8 production"], "weko_shared_id": -1}