{"_buckets": {"deposit": "4b083adc-429c-484f-86c1-509fdcc17b6f"}, "_deposit": {"id": "2016890", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2016890"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02016890", "sets": ["1642838231050", "1642838412624"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "\u500b\u5225\u5316\u533b\u7642\u306e\u5b9f\u73fe\u3092\u76ee\u6307\u3057\u3066 : 2\u578b\u7cd6\u5c3f\u75c5\u75be\u60a3\u611f\u53d7\u6027\u907a\u4f1d\u5b50\u306e\u89e3\u660e\u3068\u305d\u306e\u81e8\u5e8a\u5fdc\u7528", "subitem_1551255648112": "ja"}, {"subitem_1551255647225": "Elucidation of genetic susceptibility for type 2 diabetes and its clinical application", "subitem_1551255648112": "en"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u4eca\u6751, \u7f8e\u83dc\u5b50", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "Imamura, Minako", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "ja", "subitem_1522651041219": "\u7409\u7403\u533b\u5b66\u4f1a"}]}, "item_1617186609386": {"attribute_name": "Subject", "attribute_value_mlt": [{"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "type 2 diabetes"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "GWAS"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "genetic susceptibility"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "Clinical application"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "It has been well known that genetic susceptibility contributes to the risk for type 2 diabetes. Genome-wide association studies (GWAS) have facilitated a substantial and rapid rise in the number of confirmed susceptibility variants for type 2 diabetes. To date, more than 90 type 2 diabetes susceptibility loci have been identified through GWAS. Recently our Japanese study group conducted large-scaled GWAS meta-analysis in the Japanese populations and identified seven novel susceptibility loci for type 2 diabetes. Although the impact of the each GWAS-derived susceptibility locus to the disease risk is modest, accumulation of genetic information in individuals is useful to define a high risk group for the disease in a population. Intensive life style intervention for individuals at genetically high risk may lead efficient prevention of type 2 diabetes in the community. Because the current set of established susceptibility loci accounts for only 10% of genetic susceptibility for type 2 diabetes, more effort to search for the missing heritability would be necessary for translation of genetic information into clinical practice. Functional analysis to uncover the molecular mechanisms for type 2 diabetes susceptibility and integrated studies including genetic factor, environmental factor and interaction between genetic and environmental factors are the future challenges.", "subitem_description_type": "Other"}, {"subitem_description": "\u8ad6\u6587", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "ja", "subitem_1522300316516": "\u7409\u7403\u533b\u5b66\u4f1a"}, {"subitem_1522300295150": "en", "subitem_1522300316516": "Ryukyu Medical Association"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "jpn"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "1346-888X"}, {"subitem_1522646500366": "NCID", "subitem_1522646572813": "AN10369445"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "ja", "subitem_1522650091861": "\u7409\u7403\u533b\u5b66\u4f1a\u8a8c = Ryukyu Medical Journal"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueNumber": "1-2", "bibliographicPageEnd": "15", "bibliographicPageStart": "9", "bibliographicVolumeNumber": "36"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "v36(1-2)p9.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2016890/files/v36(1-2)p9.pdf"}, "version_id": "a942ebb5-1d47-4f38-a490-40de336a83b0"}]}, "item_title": "\u500b\u5225\u5316\u533b\u7642\u306e\u5b9f\u73fe\u3092\u76ee\u6307\u3057\u3066 : 2\u578b\u7cd6\u5c3f\u75c5\u75be\u60a3\u611f\u53d7\u6027\u907a\u4f1d\u5b50\u306e\u89e3\u660e\u3068\u305d\u306e\u81e8\u5e8a\u5fdc\u7528", "item_type_id": "15", "owner": "1", "path": ["1642838231050", "1642838412624"], "permalink_uri": "http://hdl.handle.net/20.500.12000/0002016890", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2018-12-26"}, "publish_date": "2018-12-26", "publish_status": "0", "recid": "2016890", "relation": {}, "relation_version_is_last": true, "title": ["\u500b\u5225\u5316\u533b\u7642\u306e\u5b9f\u73fe\u3092\u76ee\u6307\u3057\u3066 : 2\u578b\u7cd6\u5c3f\u75c5\u75be\u60a3\u611f\u53d7\u6027\u907a\u4f1d\u5b50\u306e\u89e3\u660e\u3068\u305d\u306e\u81e8\u5e8a\u5fdc\u7528"], "weko_shared_id": -1}