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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 36巻1-2号
  1. 部局別インデックス
  2. その他

個別化医療の実現を目指して : 2型糖尿病疾患感受性遺伝子の解明とその臨床応用

http://hdl.handle.net/20.500.12000/0002016890
http://hdl.handle.net/20.500.12000/0002016890
dce01ed9-5e8a-43be-bc48-c05de3264082
名前 / ファイル ライセンス アクション
v36(1-2)p9.pdf v36(1-2)p9.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2018-12-26
タイトル
タイトル 個別化医療の実現を目指して : 2型糖尿病疾患感受性遺伝子の解明とその臨床応用
言語 ja
作成者 今村, 美菜子

× 今村, 美菜子

ja 今村, 美菜子

Imamura, Minako

× Imamura, Minako

en Imamura, Minako

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 type 2 diabetes
言語 en
主題Scheme Other
主題 GWAS
言語 en
主題Scheme Other
主題 genetic susceptibility
言語 en
主題Scheme Other
主題 Clinical application
内容記述
内容記述タイプ Other
内容記述 It has been well known that genetic susceptibility contributes to the risk for type 2 diabetes. Genome-wide association studies (GWAS) have facilitated a substantial and rapid rise in the number of confirmed susceptibility variants for type 2 diabetes. To date, more than 90 type 2 diabetes susceptibility loci have been identified through GWAS. Recently our Japanese study group conducted large-scaled GWAS meta-analysis in the Japanese populations and identified seven novel susceptibility loci for type 2 diabetes. Although the impact of the each GWAS-derived susceptibility locus to the disease risk is modest, accumulation of genetic information in individuals is useful to define a high risk group for the disease in a population. Intensive life style intervention for individuals at genetically high risk may lead efficient prevention of type 2 diabetes in the community. Because the current set of established susceptibility loci accounts for only 10% of genetic susceptibility for type 2 diabetes, more effort to search for the missing heritability would be necessary for translation of genetic information into clinical practice. Functional analysis to uncover the molecular mechanisms for type 2 diabetes susceptibility and integrated studies including genetic factor, environmental factor and interaction between genetic and environmental factors are the future challenges.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 jpn
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346-888X
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 36, 号 1-2, p. 9-15
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