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個別化医療の実現を目指して : 2型糖尿病疾患感受性遺伝子の解明とその臨床応用
http://hdl.handle.net/20.500.12000/0002016890
http://hdl.handle.net/20.500.12000/0002016890dce01ed9-5e8a-43be-bc48-c05de3264082
名前 / ファイル | ライセンス | アクション |
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v36(1-2)p9.pdf
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Item type | デフォルトアイテムタイプ(フル)(1) | |||||||||
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公開日 | 2018-12-26 | |||||||||
タイトル | ||||||||||
タイトル | 個別化医療の実現を目指して : 2型糖尿病疾患感受性遺伝子の解明とその臨床応用 | |||||||||
言語 | ja | |||||||||
タイトル | ||||||||||
タイトル | Elucidation of genetic susceptibility for type 2 diabetes and its clinical application | |||||||||
言語 | en | |||||||||
作成者 |
今村, 美菜子
× 今村, 美菜子
× Imamura, Minako
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アクセス権 | ||||||||||
アクセス権 | open access | |||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
権利情報 | ||||||||||
言語 | ja | |||||||||
権利情報 | 琉球医学会 | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | type 2 diabetes | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | GWAS | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | genetic susceptibility | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Clinical application | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | It has been well known that genetic susceptibility contributes to the risk for type 2 diabetes. Genome-wide association studies (GWAS) have facilitated a substantial and rapid rise in the number of confirmed susceptibility variants for type 2 diabetes. To date, more than 90 type 2 diabetes susceptibility loci have been identified through GWAS. Recently our Japanese study group conducted large-scaled GWAS meta-analysis in the Japanese populations and identified seven novel susceptibility loci for type 2 diabetes. Although the impact of the each GWAS-derived susceptibility locus to the disease risk is modest, accumulation of genetic information in individuals is useful to define a high risk group for the disease in a population. Intensive life style intervention for individuals at genetically high risk may lead efficient prevention of type 2 diabetes in the community. Because the current set of established susceptibility loci accounts for only 10% of genetic susceptibility for type 2 diabetes, more effort to search for the missing heritability would be necessary for translation of genetic information into clinical practice. Functional analysis to uncover the molecular mechanisms for type 2 diabetes susceptibility and integrated studies including genetic factor, environmental factor and interaction between genetic and environmental factors are the future challenges. | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 論文 | |||||||||
出版者 | ||||||||||
言語 | ja | |||||||||
出版者 | 琉球医学会 | |||||||||
出版者 | ||||||||||
言語 | en | |||||||||
出版者 | Ryukyu Medical Association | |||||||||
言語 | ||||||||||
言語 | jpn | |||||||||
資源タイプ | ||||||||||
資源タイプ | journal article | |||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
出版タイプ | ||||||||||
出版タイプ | VoR | |||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 1346-888X | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AN10369445 | |||||||||
収録物名 | ||||||||||
言語 | ja | |||||||||
収録物名 | 琉球医学会誌 = Ryukyu Medical Journal | |||||||||
書誌情報 |
巻 36, 号 1-2, p. 9-15 |