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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 12巻4号
  1. 部局別インデックス
  2. その他

[原著]A Histochemical Comparative Study on Four Different Types of Lectins and Carcinoembryonic Antigen (CEA) on Human Colorectal Tissues

http://hdl.handle.net/20.500.12000/0002015850
http://hdl.handle.net/20.500.12000/0002015850
247a1a7a-b915-4031-a60a-1f380747567c
名前 / ファイル ライセンス アクション
v12p295.pdf v12p295.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-07-02
タイトル
タイトル [原著]A Histochemical Comparative Study on Four Different Types of Lectins and Carcinoembryonic Antigen (CEA) on Human Colorectal Tissues
言語 ja
作成者 Faisal, Muazzam A

× Faisal, Muazzam A

en Faisal, Muazzam A

Yoshihiro, Muto

× Yoshihiro, Muto

en Yoshihiro, Muto

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 colon and rectum
言語 en
主題Scheme Other
主題 neoplastic lesion
言語 en
主題Scheme Other
主題 adjacent non-neoplastic mucosa
言語 en
主題Scheme Other
主題 UEA-1 and CEA.
内容記述
内容記述タイプ Other
内容記述 To evaluate the specificity and efficacy of lectin histochemical staining characteristics on human colorectal neoplastic and adjacent non-neoplastic tissue, a thorough comparative study has been performed to that of a recognized colorectal tumor marker,carcinoembryonic antigen (CEA). Neoplastic tissue and adjacent non-neoplastic mucosa of 26 surgically extirpated specimens were examined lectin histochemically by four differentlectins (Ulex europaeus-I. Arachis hypogaea, Triticum vulgare and Canavaha ensiformis) and immunohistochemically by anti CEA antibody. According to their degree of staining all the four lectins(UEA-I moderate 57.69%, extensive 39.42%; PNA moderate 60.57% extensive 5.76%; WGA moderate 76.92% extensive 1.92% and Con-A moderate 48.07%. extensive 51.29%) and CEA (moderate 66.34%,extensive 22.11%)showed very high percentages of positive staining for neoplastic tissues but almost reciprocal results were observed by UEA-I (moderate 7.69%, extensive O%) and partially by PNA lectin (moderate 15.38%,extensive O%) for non-neoplastic mucosa (P<0.01). While CEA (moderate 50%, extensive 19.23%) and the other two lectins did not show much differences in their staining percentages for non-neoplastic mucosa (P>0.05). Further study regarding their staining pattern revealed that for neoplastic tissues UEA-I mainly stained the cytoplasmic (without polarity) (60.58%) or the stromal (28.85%) types but in case of non-neoplastic mucosa the cytoplasmic (with polarity) (57.15%) or the apical (35.71%) types predominated. No such distinct staining patterens were observed for CEA and the other lectins. From our study it is strongly suggestive that UEA-I lectinis by far morespecific and localized for the malignant transformation of colorectal tissues with compared to that of carcinoembryonic antigen, CEA.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346888X
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 12, 号 4, p. 295-306
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